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dc.contributor.authorRogers, Samantha
dc.contributor.authorHughes, Beverly A.
dc.contributor.authorTomlinson, Jeremy
dc.contributor.authorBlissett, Jacqueline
dc.date.accessioned2017-06-19T17:02:23Z
dc.date.available2017-06-19T17:02:23Z
dc.date.issued2016-11-14
dc.identifier.citationRogers , S , Hughes , B A , Tomlinson , J & Blissett , J 2016 , ' Cortisol metabolism, postnatal depression and weight changes in the first 12 months postpartum. ' , Clinical Endocrinology , vol. 85 , no. 6 , pp. 881-890 . https://doi.org/10.1111/cen.13150
dc.identifier.issn1365-2265
dc.identifier.otherPURE: 10001553
dc.identifier.otherPURE UUID: f62d2992-3ec0-4334-a690-88e454c641df
dc.identifier.otherScopus: 84994659980
dc.identifier.otherORCID: /0000-0003-0516-7929/work/62750762
dc.identifier.urihttp://hdl.handle.net/2299/18357
dc.descriptionThis is the peer-reviewed version of the following article: S. L. Rogers, B. A. Hughes, J. W. Tomlinson, and J. Blissett, 'Cortisol metabolism, postnatal depression and weight changes in the first 12 months postpartum', Clinical Endocrinology, Vol. 85 (6): 881-890, December 2016, which has been published in final form at doi: http://onlinelibrary.wiley.com/doi/10.1111/cen.13150/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.description.abstractBackground & Objectives: Postnatal depression correlates with postpartum weight retention, and dysregulated cortisol metabolism is evident in depressed individuals. Cortisol metabolism, BMI and metabolic phenotype are robustly associated, but the role of cortisol metabolism in postnatal mental health and weight loss has never been examined. Design: A longitudinal observation. Patients: Forty nine healthy women with uncomplicated pregnancy. Measurements: BMI and urinary steroid metabolites at 1 week and 1, 3, 6 and 12 months postpartum. Validated urinary steroid metabolite ratios were measured to determine the activities of 11β-hydroxysteroid dehydrogenases (11β-HSD) that interconvert inactive cortisone and active cortisol and the 5α-reductases that clear cortisol to its inactive metabolites. Postnatal depression symptoms were measured at 1, 6 and 12 months. Results: Low 5α-reductase activity was associated with greater weight loss across the first year, independent of demographics, breastfeeding and depression. Postpartum BMI change was unrelated to postnatal depression at any time. Symptoms of postnatal depression were related to higher cortisol metabolite production at 12 months, independent of demographics and breastfeeding. Conclusions: Greatest weight loss in the postpartum year was associated with lower conversion of cortisone to cortisol and lower conversion of cortisol to its metabolites, supporting previous work that demonstrates the facilitative role of lower 5α-reductase and 11β-HSD-1 in weight loss. Greater depression symptoms were associated with higher cortisol metabolite production rates. Whilst weight and mental health are both associated with dysregulation of the HPA axis, there may be different pathways towards depressed and obese phenotypes in healthy postpartum samples.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofClinical Endocrinology
dc.rightsEmbargoed
dc.titleCortisol metabolism, postnatal depression and weight changes in the first 12 months postpartum.en
dc.contributor.institutionCentre for Research in Public Health and Community Care
dc.contributor.institutionSchool of Health and Social Work
dc.contributor.institutionPublic Health and Communities
dc.contributor.institutionWeight and Obesity Research Group
dc.contributor.institutionCommunities, Young People and Family Lives
dc.description.statusPeer reviewed
dc.date.embargoedUntil2017-08-11
dc.relation.schoolSchool of Health and Social Work
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2016-11-14
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1111/cen.13150
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2017-08-11
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.date.embargo2017-08-11
herts.rights.accesstypeEmbargoed


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