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dc.contributor.authorYousif, N
dc.contributor.authorBhatt, H
dc.contributor.authorBain, P G
dc.contributor.authorNandi, D
dc.contributor.authorSeemungal, B M
dc.date.accessioned2017-06-27T15:44:03Z
dc.date.available2017-06-27T15:44:03Z
dc.date.issued2016-02-25
dc.identifier.citationYousif , N , Bhatt , H , Bain , P G , Nandi , D & Seemungal , B M 2016 , ' The effect of pedunculopontine nucleus deep brain stimulation on postural sway and vestibular perception ' , ISRN Neurology , vol. 23 , no. 3 , pp. 668-70 . https://doi.org/10.1111/ene.12947
dc.identifier.issn2090-5505
dc.identifier.urihttp://hdl.handle.net/2299/18581
dc.description© 2016 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of Europe an Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and re production in any medium, provided the original work is properly cited, see https://creativecommons.org/licenses/by/3.0/
dc.description.abstractBACKGROUND AND PURPOSE: Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) reduces the number of falls in patients with Parkinson's disease (PD). It was hypothesized that enhanced sensory processing contributes to this PPN-mediated gait improvement. METHODS: Four PD patients (and eight matched controls) with implanted bilateral PPN and subthalamic nucleus DBS electrodes were assessed on postural (with/without vision) and vestibular perceptual threshold tasks. RESULTS: Pedunculopontine nucleus ON stimulation (compared to OFF) lowered vestibular perceptual thresholds but there was a disproportionate increase in the normal sway increase on going from light to dark. CONCLUSIONS: The disproportionate increased sway with PPN stimulation in the dark may paradoxically improve balance function since mechanoreceptor signals rapidly adapt to continuous pressure stimulation from postural akinesia. Additionally, the PPN-mediated vestibular signal enhancement also improves the monitoring of postural sway. Overall, PPN stimulation may improve sensory feedback and hence balance performance.en
dc.format.extent3
dc.format.extent604494
dc.language.isoeng
dc.relation.ispartofISRN Neurology
dc.titleThe effect of pedunculopontine nucleus deep brain stimulation on postural sway and vestibular perceptionen
dc.contributor.institutionSchool of Physics, Engineering & Computer Science
dc.contributor.institutionDepartment of Engineering and Technology
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionBioEngineering
dc.contributor.institutionBiocomputation Research Group
dc.description.statusPeer reviewed
rioxxterms.versionofrecord10.1111/ene.12947
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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