dc.contributor.author | Garikipati, Rajesh | |
dc.contributor.author | Mohammed, Olufunmilayo | |
dc.contributor.author | Rossiter, Sharon | |
dc.contributor.author | Baines, Simon | |
dc.contributor.author | Bassin, Jatinder | |
dc.contributor.author | Goyal, Madhu | |
dc.date.accessioned | 2017-06-28T10:58:48Z | |
dc.date.available | 2017-06-28T10:58:48Z | |
dc.date.issued | 2015-11-26 | |
dc.identifier.citation | Garikipati , R , Mohammed , O , Rossiter , S , Baines , S , Bassin , J & Goyal , M 2015 , ' Design, Synthesis and Antimicrobial Evaluation of the in vitro Efficacy of Novel Diketones ' , Antibiotic Resistance Mechanisms Workshop (ARM 2015), Birmingham, UK , 26/11/15 - 27/11/15 . | |
dc.identifier.citation | conference | |
dc.identifier.other | ORCID: /0000-0003-3822-0028/work/142009561 | |
dc.identifier.uri | http://hdl.handle.net/2299/18614 | |
dc.description | Rajesh Garikipati, Olufunmilayo Mohammed, Sharon Rossiter, Simon Baines, Jatinder Bassin, Madhu Goyal, ‘Design, Synthesis and Antimicrobial Evaluation of the in vitro Efficacy of Novel Diketones’, poster presented at the Antibiotic Resistance Mechanisms Workshop (ARM 2015), Birmingham, UK, 26-27 November, 2015. | |
dc.description.abstract | A series of novel diketones were designed and synthesised in an attempt to develop potent antimicrobial agents. Their structures were confirmed by spectroscopic techniques i.e. 1H and 13C-NMR, IR and LC-MS. The minimum inhibitory concentration (MIC) was determined against a wide range of bacteria using two fold micro broth dilution method. Among the test Compounds DK2, DK6, DK7, DK11, DK12, DK16 and DK17 were found to have excellent activity against all Gram positive bacteria with MIC values ranging 16-0.1μg/ml. The in vitro cytotoxity of all the active compounds was assessed by MTT clorimetric assay. The bioactive compounds exhibited IC50 values against Caco-2 cells rainging 64-8ug/ml | en |
dc.language.iso | eng | |
dc.title | Design, Synthesis and Antimicrobial Evaluation of the in vitro Efficacy of Novel Diketones | en |
dc.contributor.institution | Veterinary Science | |
dc.contributor.institution | Microbiology and Biotechnology | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Natural Product Chemistry and Drug Design | |
dc.contributor.institution | Biosciences Research Group | |
dc.contributor.institution | Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit | |
dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | Centre for Future Societies Research | |
dc.description.status | Non peer reviewed | |
rioxxterms.type | Other | |
herts.preservation.rarelyaccessed | true | |