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dc.contributor.authorCelis-Morales, Carlos
dc.contributor.authorLivingstone, Katherine M
dc.contributor.authorMarsaux, Cyril F M
dc.contributor.authorMacready, Anna L
dc.contributor.authorFallaize, Rosalind
dc.contributor.authorO'Donovan, Clare B
dc.contributor.authorWoolhead, Clara
dc.contributor.authorForster, Hannah
dc.contributor.authorWalsh, Marianne C
dc.contributor.authorNavas-Carretero, Santiago
dc.contributor.authorSan-Cristobal, Rodrigo
dc.contributor.authorTsirigoti, Lydia
dc.contributor.authorLambrinou, Christina P
dc.contributor.authorMavrogianni, Christina
dc.contributor.authorMoschonis, George
dc.contributor.authorKolossa, Silvia
dc.contributor.authorHallmann, Jacqueline
dc.contributor.authorGodlewska, Magdalena
dc.contributor.authorSurwiłło, Agnieszka
dc.contributor.authorTraczyk, Iwona
dc.contributor.authorDrevon, Christian A
dc.contributor.authorBouwman, Jildau
dc.contributor.authorvan Ommen, Ben
dc.contributor.authorGrimaldi, Keith
dc.contributor.authorParnell, Laurence D
dc.contributor.authorMatthews, John N S
dc.contributor.authorManios, Yannis
dc.contributor.authorDaniel, Hannelore
dc.contributor.authorMartinez, J Alfredo
dc.contributor.authorLovegrove, Julie A
dc.contributor.authorGibney, Eileen R
dc.contributor.authorBrennan, Lorraine
dc.contributor.authorSaris, Wim H M
dc.contributor.authorGibney, Mike
dc.contributor.authorMathers, John C
dc.contributor.authorFood4Me Study
dc.date.accessioned2017-06-29T16:13:02Z
dc.date.available2017-06-29T16:13:02Z
dc.date.issued2017-04-01
dc.identifier.citationCelis-Morales , C , Livingstone , K M , Marsaux , C F M , Macready , A L , Fallaize , R , O'Donovan , C B , Woolhead , C , Forster , H , Walsh , M C , Navas-Carretero , S , San-Cristobal , R , Tsirigoti , L , Lambrinou , C P , Mavrogianni , C , Moschonis , G , Kolossa , S , Hallmann , J , Godlewska , M , Surwiłło , A , Traczyk , I , Drevon , C A , Bouwman , J , van Ommen , B , Grimaldi , K , Parnell , L D , Matthews , J N S , Manios , Y , Daniel , H , Martinez , J A , Lovegrove , J A , Gibney , E R , Brennan , L , Saris , W H M , Gibney , M , Mathers , J C & Food4Me Study 2017 , ' Effect of personalized nutrition on health-related behaviour change : evidence from the Food4me European randomized controlled trial ' International Journal of Epidemiology , vol. 46 , no. 2 , pp. 578-588 . https://doi.org/10.1093/ije/dyw186
dc.identifier.issn0300-5771
dc.identifier.otherPURE: 10520533
dc.identifier.otherPURE UUID: f1cc836f-2dc9-4e0f-ba65-0c194bc81f44
dc.identifier.otherPubMed: 27524815
dc.identifier.otherScopus: 85030185992
dc.identifier.urihttp://hdl.handle.net/2299/18693
dc.descriptionThis is a pre-copyedited, author-produced version of an article accepted for publication in International Journal of Epidemiology following peer review. The version of record [Carlos Celis-Morales, et al, 'Effect of personalized nutrition on health-related behaviour change: evidence from the Food4Me European randomized controlled trail', International Journal of Epidemiology, Vol. 46 (2): 578-588, August 2016] is available online at: https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dyw186.
dc.description.abstractBACKGROUND: Optimal nutritional choices are linked with better health, but many current interventions to improve diet have limited effect. We tested the hypothesis that providing personalized nutrition (PN) advice based on information on individual diet and lifestyle, phenotype and/or genotype would promote larger, more appropriate, and sustained changes in dietary behaviour. METHODS: Adults from seven European countries were recruited to an internet-delivered intervention (Food4Me) and randomized to: (i) conventional dietary advice (control) or to PN advice based on: (ii) individual baseline diet; (iii) individual baseline diet plus phenotype (anthropometry and blood biomarkers); or (iv) individual baseline diet plus phenotype plus genotype (five diet-responsive genetic variants). Outcomes were dietary intake, anthropometry and blood biomarkers measured at baseline and after 3 and 6 months' intervention. RESULTS: At baseline, mean age of participants was 39.8 years (range 18-79), 59% of participants were female and mean body mass index (BMI) was 25.5 kg/m(2) From the enrolled participants, 1269 completed the study. Following a 6-month intervention, participants randomized to PN consumed less red meat [-5.48 g, (95% confidence interval:-10.8,-0.09), P = 0.046], salt [-0.65 g, (-1.1,-0.25), P = 0.002] and saturated fat [-1.14 % of energy, (-1.6,-0.67), P < 0.0001], increased folate [29.6 µg, (0.21,59.0), P = 0.048] intake and had higher Healthy Eating Index scores [1.27, (0.30, 2.25), P = 0.010) than those randomized to the control arm. There was no evidence that including phenotypic and phenotypic plus genotypic information enhanced the effectiveness of the PN advice. CONCLUSIONS: Among European adults, PN advice via internet-delivered intervention produced larger and more appropriate changes in dietary behaviour than a conventional approach.en
dc.format.extent11
dc.language.isoeng
dc.relation.ispartofInternational Journal of Epidemiology
dc.rights/dk/atira/pure/core/openaccesspermission/embargoed
dc.subjectpersonalized nutrition
dc.subjectinternet-based
dc.subjectrandomized controlled trial
dc.subjectgenotype
dc.subjectphenotype
dc.subjectobesity
dc.subjectdiet
dc.subjectmetabolic health
dc.titleEffect of personalized nutrition on health-related behaviour change : evidence from the Food4me European randomized controlled trialen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.contributor.institutionWeight and Obesity Research Group
dc.description.statusPeer reviewed
dc.date.embargoedUntil2017-08-12
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2016-06-07
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1093/ije/dyw186
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2017-08-12+01:00
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.date.embargo2017-08-12+01:00
herts.rights.accesstypeopenAccess


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