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dc.contributor.authorShamsaldeen, Yousif
dc.contributor.authorMacKenzie, Louise
dc.contributor.authorLione, Lisa
dc.contributor.authorBenham, Christopher
dc.date.accessioned2017-07-03T16:18:22Z
dc.date.available2017-07-03T16:18:22Z
dc.date.issued2016-05
dc.identifier.citationShamsaldeen , Y , MacKenzie , L , Lione , L & Benham , C 2016 , ' Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies ' , Current Drug Metabolism , vol. 17 , no. 4 , pp. 359-367 . https://doi.org/10.2174/1389200217666151222155216
dc.identifier.issn1875-5453
dc.identifier.urihttp://hdl.handle.net/2299/18730
dc.descriptionThe published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1389200217666151222155216 © 2018 Bentham Science Publishers
dc.description.abstractBackground: Diabetes mellitus (DM) is a pandemic metabolic disease characterized by a chronically elevated blood glucose concentration (hyperglycemia) due to insulin dysfunction. Approximately 50% of diabetics show diabetes complications by the time they are diagnosed. Vascular dysfunction, nephropathy and neuropathic pain are common diabetes complications. Chronic hyperglycemia contributes to reactive oxygen species (ROS) generation such as methylglyoxal (MGO). Methods: Peer reviewed research papers were studied through bibliographic databases searching focused on review questions and inclusion/exclusion criteria. The reviewed papers were appraised according to the searching focus. The characteristics of screened papers were described, and a deductive qualitative content analysis methodology was applied to the included studies using a conceptual framework to yield this comprehensive systematic review. Results: Sixty-six papers were included in this review. Eleven papers related methylglyoxal generation to carbohydrates metabolism, ten papers related lipid metabolism to methylglyoxal and 5 papers showed the proteolytic pathways that contribute to methylglyoxal generation. Methylglyoxal metabolism was derived from 7 papers. Descriptive figure 1 was drawn to explain methylglyoxal sources and how diabetes increases methylglyoxal generation. Furthermore, twenty-six papers related methylglyoxal to diabetes complications from which 9 papers showed methylglyoxal ability to induce insulin dysfunction, an effect which was described in schematic figure 2. Additionally, fifteen papers revealed methylglyoxal contribution to vascular dysfunction and 3 papers showed methylglyoxal to cause neuropathic pain. Methylglyoxal-induced vascular dysfunction was drawn in a comprehensive figure 3. This review correlated methylglyoxal with diabetes and diabetes complications which were summarised in table 1. Conclusion: The findings of this review suggesting methylglyoxal as an essential therapeutic target for managing diabetes in the future.en
dc.format.extent9
dc.format.extent1165904
dc.language.isoeng
dc.relation.ispartofCurrent Drug Metabolism
dc.subjectDiabetes
dc.subjectendothelial dysfunction
dc.subjectretinopathy
dc.subjectneuropathic pain
dc.subjectnephropathy
dc.subjectmethylglyoxal
dc.subjectinsulin
dc.subjectglucose
dc.titleMethylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathiesen
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionCardiovascular Pathologies
dc.contributor.institutionDiabetic neuropathies
dc.contributor.institutionTRP Ion channels
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionBasic and Clinical Science Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionCentre for Research in Mechanisms of Disease and Drug Discovery
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.description.statusPeer reviewed
dc.date.embargoedUntil2017-05-01
dc.identifier.urlhttp://www.ingentaconnect.com/search/article?option1=tka&value1=Methylglyoxal%2c+A+Metabolite+Increased+in+Diabetes+is+Associated+with+Insulin+Resistance%2c+Vascular+Dysfunction+and+Neuropathies&pageSize=10&index=1#expand/collapse
rioxxterms.versionofrecord10.2174/1389200217666151222155216
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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