dc.contributor.author | Cook, Michael | |
dc.date.accessioned | 2017-07-05T15:58:22Z | |
dc.date.available | 2017-07-05T15:58:22Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Cook , M 2016 , ' Mucosa-mimetic materials to replace animal tissue in mucoadhesion research ' , Doctor Hadwen Trust Animal Replacement Science Conference , 9/12/16 . | |
dc.identifier.citation | conference | |
dc.identifier.uri | http://hdl.handle.net/2299/18800 | |
dc.description | Michael Cook, 'Mucosa-mimetic materials to replace animal tissue in mucoadhesion research', poster presented at the Doctor Hadwen Trust Animal Replacement Science Conference, London, UK, 9 December, 2016. | |
dc.description.abstract | Pharmaceutical scientists often wish to design dosage forms which adhere to mucosal membranes to provide a localised effect. These “mucoadhesive” formulations are typically evaluated using ex vivo animal tissue, a large amount of which is sourced from laboratory animals slaughtered for that tissue . The authors aim to produce a synthetic alternative to this tissue, which frees scientists from the need to use laboratory animals and provides a substrate which is inexpensive and homogenous. A substrate containing 20 mol% N-acryloylglucosamine (AGA) and 80 mol% 2- hydroxyethylmethacrylate (HEMA) was identified as being an effective mimic for buccal mucosa when testing the mucoadhesion of tablets. This study investigates the efficacy of this “mucosa-mimetic” material when testing for the mucoadhesion of liquid and semi-solid dosage forms. | en |
dc.format.extent | 767352 | |
dc.language.iso | eng | |
dc.title | Mucosa-mimetic materials to replace animal tissue in mucoadhesion research | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Pharmacy, Pharmacology and Postgraduate Medicine | |
dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
dc.description.status | Non peer reviewed | |
rioxxterms.type | Other | |
herts.preservation.rarelyaccessed | true | |