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dc.contributor.authorVilar, Enric
dc.contributor.authorFarrington, Ken
dc.identifier.citationVilar , E & Farrington , K 2011 , ' Emerging importance of residual renal function in end-stage renal failure ' , Seminars in Dialysis , vol. 24 , no. 5 , pp. 487-94 .
dc.identifier.otherPURE: 10604684
dc.identifier.otherPURE UUID: 32959f1a-26b6-4d15-af63-b33aaffc4fb2
dc.identifier.otherPubMed: 21999737
dc.identifier.otherScopus: 80054697062
dc.description© 2011 Wiley Periodicals, Inc.
dc.description.abstractResidual renal function (RRF) is well recognized as an important marker of outcomes in peritoneal dialysis (PD), and contributes vitally to solute clearance. Recently, its importance in hemodialysis (HD) has emerged with evidence that it is strongly associated with improved outcomes. The presence of RRF is associated with improved nutrition, reduced erythropoetin requirements, better potassium clearance, and improved quality of life. Retrospective and observational evidence is now available, which suggests that the presence of RRF is independently associated with survival and that this benefit goes beyond what is expected simply from augmentation of small solute clearance. Preservation of RRF is now considered by many to be an important aspect of dialysis strategy. Evidence in favor of one modality over another for preservation of RRF is conflicting, as are the potential benefits of biocompatible fluids in PD. In HD, the evidence in favor of biocompatible membranes is stronger. Emerging evidence is broadly in favor of angiotensin converting enzyme inhibitors for preservation of RRF. Diuretics appear to have a neutral effect. The complexities and practical difficulties in measurement of RRF have resulted in this important parameter being largely ignored in HD. Novel markers of renal function may provide alternative, simple methods of estimating RRF, which may remove the need for urine collections and simplify its measurement.en
dc.relation.ispartofSeminars in Dialysis
dc.subjectKidney Failure, Chronic
dc.subjectKidney Function Tests
dc.subjectRenal Dialysis
dc.subjectSurvival Rate
dc.titleEmerging importance of residual renal function in end-stage renal failureen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionBasic and Clinical Science Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences

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