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        Measuring Residual Renal Function in Hemodialysis Patients without Urine Collection

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        Author
        Wong, Jonathan
        Kaja Kamal, Raja Mohammed
        Vilar, Enric
        Farrington, Kenneth
        Attention
        2299/18875
        Abstract
        Many patients on hemodialysis retain significant residual renal function (RRF) but currently measurement of RRF in routine clinical practice can only be achieved using inter-dialytic urine collections to measure urea and creatinine clearances. Urine collections are difficult and inconvenient for patients and staff, and therefore RRF is not universally measured. Methods to assess RRF without reliance on urine collections are needed since RRF provides useful clinical and prognostic information and also permits the application of incremental hemodialysis techniques. Significant efforts have been made to explore the use of serum based biomarkers such as cystatin C, β-trace protein and β2 -microglobulin to estimate RRF. This article reviews blood-based biomarkers and novel methods using exogenous filtration markers which show potential in estimating RRF in hemodialysis patients without the need for urine collection.
        Publication date
        2017-01-02
        Published in
        Seminars in Dialysis
        Published version
        https://doi.org/10.1111/sdi.12557
        Other links
        http://hdl.handle.net/2299/18875
        Relations
        School of Life and Medical Sciences
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