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dc.contributor.authorBunn, Frances
dc.contributor.authorGoodman, Claire
dc.contributor.authorLivingston, Gill
dc.date.accessioned2017-07-13T17:08:28Z
dc.date.available2017-07-13T17:08:28Z
dc.date.issued2017-06-29
dc.identifier.citationBunn , F , Goodman , C & Livingston , G 2017 , ' Core Outcome Measures for interventions to prevent or slow the progress of dementia for people living with mild to moderate dementia: systematic review and consensus recommendations ' , PLoS ONE . https://doi.org/10.1371/journal.pone.0179521
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 11903782
dc.identifier.otherPURE UUID: 825288de-049d-4c73-9a19-bd7a8f6c5ba7
dc.identifier.otherScopus: 85021661906
dc.identifier.urihttp://hdl.handle.net/2299/18935
dc.description© 2017 Webster et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.description.abstractBackground There are no disease-modifying treatments for dementia. There is also no consensus on disease modifying outcomes. We aimed to produce the first evidence-based consensus on core outcome measures for trials of disease modification in mild-to-moderate dementia. Methods and Findings We defined disease-modification interventions as those aiming to change the underlying pathology. We systematically searched electronic databases and previous systematic reviews for published and ongoing trials of disease-modifying treatments in mild-to-moderate dementia. We included 149/22,918 of the references found; with 81 outcome measures from 125 trials. Trials involved participants with Alzheimer’s disease (AD) alone (n = 111), or AD and mild cognitive impairment (n = 8) and three vascular dementia. We divided outcomes by the domain measured (cognition, activities of daily living, biological markers, neuropsychiatric symptoms, quality of life, global). We calculated the number of trials and of participants using each outcome. We detailed psychometric properties of each outcome. We sought the views of people living with dementia and family carers in three cities through Alzheimer’s society focus groups. Attendees at a consensus conference (experts in dementia research, disease-modification and harmonisation measures) decided on the core set of outcomes using these results. Recommended core outcomes were cognition as the fundamental deficit in dementia and to indicate disease modification, serial structural MRIs. Cognition should be measured by Mini Mental State Examination or Alzheimer's Disease Assessment Scale-Cognitive Subscale. MRIs would be optional for patients. We also made recommendations for measuring important, but non-core domains which may not change despite disease modification. Limitations Most trials were about AD. Specific instruments may be superseded. We searched one database for psychometric properties. Interpretation This is the first review to identify the 81 outcome measures the research community uses for disease-modifying trials in mild-to-moderate dementia. Our recommendations will facilitate designing, comparing and meta-analysing disease modification trials in mild-to-moderate dementia, increasing their value. Registration PROSPERO no. CRD42015027346.en
dc.language.isoeng
dc.relation.ispartofPLoS ONE
dc.titleCore Outcome Measures for interventions to prevent or slow the progress of dementia for people living with mild to moderate dementia: systematic review and consensus recommendationsen
dc.contributor.institutionSchool of Health and Social Work
dc.contributor.institutionDepartment of Adult Nursing and Primary Care
dc.contributor.institutionCentre for Research in Public Health and Community Care
dc.contributor.institutionEvidence Based Practice
dc.contributor.institutionNursing, Midwifery and Social Work
dc.contributor.institutionOlder People's Health and Complex Conditions
dc.contributor.institutionWeight and Obesity Research Group
dc.description.statusPeer reviewed
dc.relation.school
dcterms.dateAccepted2017-06-29
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1371/journal.pone.0179521
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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