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dc.contributor.authorMatar, Hazem
dc.contributor.authorGuerreiro, Antonio
dc.contributor.authorPiletsky, Sergey A.
dc.contributor.authorPrice, Shirley
dc.contributor.authorChilcott, Robert
dc.date.accessioned2017-07-14T14:40:34Z
dc.date.available2017-07-14T14:40:34Z
dc.date.issued2016-04-02
dc.identifier.citationMatar , H , Guerreiro , A , Piletsky , S A , Price , S & Chilcott , R 2016 , ' Preliminary evaluation of military, commercial and novel skin decontamination products against a chemical warfare agent simulant (methyl salicylate) ' , Cutaneous and Ocular Toxicology , vol. 35 , no. 2 , pp. 137-144 . https://doi.org/10.3109/15569527.2015.1072544
dc.identifier.issn1556-9527
dc.identifier.otherPURE: 8195616
dc.identifier.otherPURE UUID: bb3df2a5-d218-44a9-9f41-d3c47d1ec3e3
dc.identifier.otherPubMed: 26339920
dc.identifier.otherScopus: 84940785324
dc.identifier.urihttp://hdl.handle.net/2299/18952
dc.descriptionThis is an Accepted Manuscript of an article published by Taylor & Francis in Cutaneous and Ocular Toxicology on 13 August 2015, available online: http://www.tandfonline.com/doi/full/10.3109/15569527.2015.1072544.
dc.description.abstractRapid decontamination is vital to alleviate adverse health effects following dermal exposure to hazardous materials. There is an abundance of materials and products which can be utilised to remove hazardous materials from the skin. In this study, a total of 15 products were evaluated, 10 of which were commercial or military products and 5 were novel (molecular imprinted) polymers. The efficacies of these products were evaluated against a 10µL droplet of 14C-methyl salicylate applied to the surface of porcine skin mounted on static diffusion cells. The current UK military decontaminant (Fuller’s earth) performed well, retaining 83% of the dose over 24 hours and served as a benchmark to compare with the other test products. The five most effective test products were Fuller’s earth (the current UK military decontaminant), Fast-Act® and three novel polymers (based on itaconic acid, 2-trifluoromethylacrylic acid and N,N-methylene bis acrylamide). Five products (medical moist free wipes, 5% FloraFree™ solution, normal baby wipes, baby wipes for sensitive skin and Diphotérine™) enhanced the dermal absorption of 14C-methyl salicylate. Further work is required to establish the performance of the most effective products identified in this study against chemical warfare agents.en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofCutaneous and Ocular Toxicology
dc.rightsEmbargoed
dc.subjectAbsorbent
dc.subjectchemical warfare agent
dc.subjectdecontamination
dc.subjectmethyl salicylate
dc.subjectpercutaneous absorption
dc.subjectskin
dc.titlePreliminary evaluation of military, commercial and novel skin decontamination products against a chemical warfare agent simulant (methyl salicylate)en
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionToxicology
dc.description.statusPeer reviewed
dc.date.embargoedUntil2016-08-13
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2016-04-02
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.3109/15569527.2015.1072544
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeEmbargoed


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