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        Lurasidone in the Treatment of Bipolar Depression: : Systematic Review of Systematic Reviews

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        3084859.pdf (PDF, 1Mb)
        Author
        Fornaro, Michele
        De Berardis, Domenico
        Perna, Giampaolo
        Solmi, Marco
        Veronese, Nicola
        Orsolini, Laura
        Buonaguro, Elisabetta Filomena
        Iasevoli, Felice
        Köhler, Cristiano André
        Carvalho, André Ferrer
        De Bartolomeis, Andrea
        Attention
        2299/19092
        Abstract
        Introduction. A burgeoning number of systematic reviews considering lurasidone in the treatment of bipolar depression have occurred since its Food and Drug Administration extended approval in 2013. While a paucity of available quantitative evidence still precludes preliminary meta-analysis on the matter, the present quality assessment of systematic review of systematic reviews, nonetheless, aims at highlighting current essential information on the topic. Methods. Both published and unpublished systematic reviews about lurasidone mono- or adjunctive therapy in the treatment of bipolar depression were searched by two independent authors inquiring PubMed/Cochrane/Embase/Scopus from inception until October 2016. Results. Twelve included systematic reviews were of moderate-to-high quality and consistent in covering the handful of RCTs available to date, suggesting the promising efficacy, safety, and tolerability profile of lurasidone. Concordance on the drug profile seems to be corroborated by a steadily increasing number of convergent qualitative reports on the matter. Limitations. Publication, sponsorship, language, citation, and measurement biases. Conclusions. Despite being preliminary in nature, this overview stipulates the effectiveness of lurasidone in the acute treatment of Type I bipolar depression overall. As outlined by most of the reviewed evidence, recommendations for future research should include further controlled trials of extended duration.
        Publication date
        2017-05-09
        Published in
        BioMed Research International
        Published version
        https://doi.org/10.1155/2017/3084859
        Other links
        http://hdl.handle.net/2299/19092
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