Show simple item record

dc.contributor.authorFallaize, Rosalind
dc.contributor.authorCarvalho-Wells, Andrew L
dc.contributor.authorTierney, Audrey C
dc.contributor.authorMarin, Carmen
dc.contributor.authorKieć-Wilk, Beata
dc.contributor.authorDembińska-Kieć, Aldona
dc.contributor.authorDrevon, Christian A.
dc.contributor.authorDeFoort, Catherine
dc.contributor.authorLopez-Miranda, José
dc.contributor.authorRisérus, Ulf
dc.contributor.authorSaris, Wim H.
dc.contributor.authorBlaak, Ellen E
dc.contributor.authorRoche, Helen M
dc.contributor.authorLovegrove, Julie A
dc.date.accessioned2017-08-31T16:20:56Z
dc.date.available2017-08-31T16:20:56Z
dc.date.issued2017-07-24
dc.identifier.citationFallaize , R , Carvalho-Wells , A L , Tierney , A C , Marin , C , Kieć-Wilk , B , Dembińska-Kieć , A , Drevon , C A , DeFoort , C , Lopez-Miranda , J , Risérus , U , Saris , W H , Blaak , E E , Roche , H M & Lovegrove , J A 2017 , ' APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome ' , Scientific Reports , vol. 7 , 6274 . https://doi.org/10.1038/s41598-017-05802-2
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 11926914
dc.identifier.otherPURE UUID: 0a6c947a-32be-40d9-bf1b-64f048139089
dc.identifier.otherScopus: 85026263570
dc.identifier.urihttp://hdl.handle.net/2299/19264
dc.descriptionThis is an Open Access article licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2017.
dc.description.abstractMetabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and FA status on metabolic markers in MetS. Plasma FA, blood pressure, insulin sensitivity and lipid concentrations were determined at baseline and following a 12-week randomized, controlled, parallel, dietary FA intervention in 442 adults with MetS (LIPGENE study). FA-APOE gene interactions at baseline and following change in plasma FA were assessed using adjusted general linear models. At baseline E4 carriers had higher plasma concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) compared with E2 carriers; and higher TC, LDL-C and apo B compared with E3/E3. Whilst elevated plasma n-3 polyunsaturated FA (PUFA) was associated with a beneficially lower concentration of apo CIII in E2 carriers, a high proportion of plasma C16:0 was associated with insulin resistance in E4 carriers. Following FA intervention, a reduction in plasma long-chain n-3 PUFA was associated with a reduction in apo CII concentration in E2 carriers. Our novel data suggest that individuals with MetS may benefit from personalized dietary interventions based on APOE genotype.en
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.rightsOpen
dc.subjectdiagnostic markers
dc.subjectlifestyle modification
dc.subjectmetabolic syndrome
dc.subjectNutrigenomics
dc.titleAPOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndromeen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.contributor.institutionWeight and Obesity Research Group
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2017-07-24
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1038/s41598-017-05802-2
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record