dc.contributor.author | White, M T | |
dc.contributor.author | Lwetoijera, D | |
dc.contributor.author | Marshall, J. | |
dc.contributor.author | Caron-Lormier, G | |
dc.contributor.author | Bohan, D. A. | |
dc.contributor.author | Denholm, Ian | |
dc.contributor.author | Devine, GJ | |
dc.date.accessioned | 2017-09-14T16:43:03Z | |
dc.date.available | 2017-09-14T16:43:03Z | |
dc.date.issued | 2014-05-01 | |
dc.identifier.citation | White , M T , Lwetoijera , D , Marshall , J , Caron-Lormier , G , Bohan , D A , Denholm , I & Devine , GJ 2014 , ' Negative cross resistance mediated by co-treated bed nets: a potential means of restoring pyrethroid-susceptibility to malaria vectors ' , PLoS ONE , vol. 9 , no. 5 , e95640 . https://doi.org/10.1371/journal.pone.0095640 | |
dc.identifier.other | ORCID: /0000-0001-9797-874X/work/62750624 | |
dc.identifier.uri | http://hdl.handle.net/2299/19393 | |
dc.description | © 2014 White et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.description.abstract | Insecticide-treated nets and indoor residual spray programs for malaria control are entirely dependent on pyrethroid insecticides. The ubiquitous exposure of Anopheles mosquitoes to this chemistry has selected for resistance in a number of populations. This threatens the sustainability of our most effective interventions but no operationally practicable way of resolving the problem currently exists. One innovative solution involves the co-application of a powerful chemosterilant (pyriproxyfen or PPF) to bed nets that are usually treated only with pyrethroids. Resistant mosquitoes that are unaffected by the pyrethroid component of a PPF/pyrethroid co-treatment remain vulnerable to PPF. There is a differential impact of PPF on pyrethroid-resistant and susceptible mosquitoes that is modulated by the mosquito’s behavioural response at co-treated surfaces. This imposes a specific fitness cost on pyrethroid-resistant phenotypes and can reverse selection. The concept is demonstrated using a mathematical model. | en |
dc.format.extent | 7 | |
dc.format.extent | 947968 | |
dc.language.iso | eng | |
dc.relation.ispartof | PLoS ONE | |
dc.subject | General Agricultural and Biological Sciences | |
dc.title | Negative cross resistance mediated by co-treated bed nets: a potential means of restoring pyrethroid-susceptibility to malaria vectors | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Biological and Environmental Sciences | |
dc.contributor.institution | Agriculture, Food and Veterinary Sciences | |
dc.contributor.institution | Geography, Environment and Agriculture | |
dc.contributor.institution | Crop Protection and Climate Change | |
dc.contributor.institution | Ecology | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1371/journal.pone.0095640 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |