dc.contributor.author | Parisini, Irene | |
dc.contributor.author | Collett, James L. | |
dc.contributor.author | Murnane, Darragh | |
dc.date.accessioned | 2017-11-30T17:55:31Z | |
dc.date.available | 2017-11-30T17:55:31Z | |
dc.date.issued | 2015-12-01 | |
dc.identifier.citation | Parisini , I , Collett , J L & Murnane , D 2015 , ' Mathematical approach for understanding deagglomeration behaviour of drug powder in formulations with coarse carrier ' , Asian Journal of Pharmaceutical Sciences , vol. 10 , no. 6 , pp. 501-512 . https://doi.org/10.1016/j.ajps.2015.08.007 | |
dc.identifier.issn | 1818-0876 | |
dc.identifier.uri | http://hdl.handle.net/2299/19580 | |
dc.description | This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. | |
dc.description.abstract | Deagglomeration of cohesive particles in combination with coarse carrier is a key requirement for inhaled formulations. The aim of the project was to propose a mathematical approach to understand aerosolization behaviour of micronized particles alone and in formulation with carriers. Salbutamol sulphate and salmeterol xinafoate were blended separately with fine lactose (ratio 1:4) and fine and coarse lactose (1:4:63.5). Laser diffraction was employed to characterize the powder median particle size. The deagglomeration of micronized materials followed an asymptotic monoexponential relationship. When the coarse lactose was added, the relationship fitted a bi-exponential equation showing an easily and a poorly dispersed fraction. Using model hydrophobic and hydrophilic APIs, this study has demonstrated the utility of an analytical approach that can parameterize deagglomeration behaviour of carrier-free and carrier-based inhalation formulations. The analytical approach provides the ability to systematically study the effect of material, formulation and processing factors on deagglomeration behaviour. | en |
dc.format.extent | 12 | |
dc.format.extent | 3913348 | |
dc.language.iso | eng | |
dc.relation.ispartof | Asian Journal of Pharmaceutical Sciences | |
dc.subject | Cohesive powders | |
dc.subject | Deagglomeration | |
dc.subject | Non-linear regression modelling | |
dc.subject | Ternary agents | |
dc.subject | Pharmacology | |
dc.subject | Pharmaceutical Science | |
dc.title | Mathematical approach for understanding deagglomeration behaviour of drug powder in formulations with coarse carrier | en |
dc.contributor.institution | Department of Pharmacy | |
dc.contributor.institution | University of Hertfordshire | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=84959557337&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1016/j.ajps.2015.08.007 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |