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dc.contributor.authorShan, Dehong
dc.contributor.authorXie, Yongling
dc.contributor.authorRen, Guogang
dc.contributor.authorYang, Zhuo
dc.date.accessioned2017-12-12T17:07:03Z
dc.date.available2017-12-12T17:07:03Z
dc.date.issued2012-03-07
dc.identifier.citationShan , D , Xie , Y , Ren , G & Yang , Z 2012 , ' Inhibitory effect of tungsten carbide nanoparticles on voltage-gated potassium currents of hippocampal CA1 neurons ' Toxicology Letters , vol 209 , no. 2 , pp. 129-135 . DOI: 10.1016/j.toxlet.2011.12.001
dc.identifier.issn0378-4274
dc.identifier.otherPURE: 12927328
dc.identifier.otherPURE UUID: 1d919c86-267e-4c3d-9564-22c6fa4d9f1a
dc.identifier.otherScopus: 84862812425
dc.identifier.otherPubMed: 22192952
dc.identifier.urihttp://hdl.handle.net/2299/19602
dc.description.abstractThe effects of tungsten carbide nanoparticles (nano-WC) on the properties of voltage-dependent potassium currents and evoked action potentials were studied in the hippocampal CA1 pyramidal neurons of rats at the ages of postnatal days 10-14 using the whole-cell patch-clamp technique. The results indicated that: (1) the amplitudes of transient outward potassium current (I A) and delayed rectifier potassium current (I K) were significantly decreased by 10 -7g/ml nano-WC, while the current-voltage curves of I A and I K were significantly decreased by nano-WC from +10 to +90mV. (2) Nano-WC produced a depolarizing shift in the steady-state activation curve of I A and I K with increased slope factors, and delayed the recovery of I A from inactivation, but no significant effects were found on the inactivation of I A. (3) Nano-WC prolonged the evoked action potential duration and lowered the firing rate. These results suggest that 10 -7g/ml nano-WC can decrease the amplitudes of I A and I K currents by reducing the opening number of voltage-gated potassium channels and delaying the recovery of I A from inactivation, which indicate that nano-WC has the potential neurotoxicity.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofToxicology Letters
dc.subjectDelayed rectifier potassium current
dc.subjectHippocampus
dc.subjectNeurotoxicity
dc.subjectTransient outward potassium current
dc.subjectTungsten carbide nanoparticles
dc.subjectToxicology
dc.titleInhibitory effect of tungsten carbide nanoparticles on voltage-gated potassium currents of hippocampal CA1 neuronsen
dc.contributor.institutionUniversity of Hertfordshire
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84862812425&partnerID=8YFLogxK
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.toxlet.2011.12.001
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


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