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dc.contributor.authorLi, Pan
dc.contributor.authorAsokanathanb, Catpagavalli
dc.contributor.authorLiu, Fang
dc.contributor.authorKhaing, Kyi Kyi
dc.contributor.authorKmiec, Dorota
dc.contributor.authorWei, Xiaoqing
dc.contributor.authorSong, Bin
dc.contributor.authorXing, Dorothy
dc.contributor.authorKong, Deling
dc.date.accessioned2018-01-30T22:12:16Z
dc.date.available2018-01-30T22:12:16Z
dc.date.issued2016-11-20
dc.identifier.citationLi , P , Asokanathanb , C , Liu , F , Khaing , K K , Kmiec , D , Wei , X , Song , B , Xing , D & Kong , D 2016 , ' PLGA nano/micro particles encapsulated with pertussis toxoid (PTd) enhances Th1/Th17 immune response in a murine model ' , International Journal of Pharmaceutics , vol. 513 , no. 1-2 , pp. 183-190 . https://doi.org/10.1016/j.ijpharm.2016.08.059
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 11091922
dc.identifier.otherPURE UUID: b859ef72-b0e9-4a46-af3a-b361f838604b
dc.identifier.otherScopus: 84986250445
dc.identifier.urihttp://hdl.handle.net/2299/19639
dc.descriptionThis document is the Accepted Manuscript version of the following article: Pan Li, Catpagavalli Asokanathan, Fang Liu, Kyi Kyi Khaing, Dorota Kmiec, Xiaoqing Wei, Sing Song, Dorothy Xing, and Deling Kong, ‘PLGA nano/micro particles encapsulated with pertussis toxoid (PTd) enhances Th1/Th17 immune response in a murine model’, International Journal of Pharmaceutics, Vol. 513 (1-2): 183-190, November 2016, available online at: https://doi.org/10.1016/j.ijpharm.2016.08.059. This manuscript version is made available under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives LicenseCC BY NC-ND 4.0 ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
dc.description.abstractPoly(lactic-co-glycolic acid) (PLGA) based nano/micro particles were investigated as a potential vaccine platform for pertussis antigen. Presentation of pertussis toxoid as nano/micro particles (NP/MP) gave similar antigen-specific IgG responses in mice compared to soluble antigen. Notably, in cell line based assays, it was found that PLGA based nano/micro particles enhanced the phagocytosis of fluorescent antigen-nano/micro particles by J774.2 murine monocyte/macrophage cells compared to soluble antigen. More importantly, when mice were immunised with the antigen-nano/micro particles they significantly increased antigen-specific Th1 cytokines INF-γ and IL-17 secretion in splenocytes after in vitro re-stimulation with heat killed Bordetalla pertussis, indicating the induction of a Th1/Th17 response. Also, presentation of pertussis antigen in a NP/MP formulation is able to provide protection against respiratory infection in a murine model. Thus, the NP/MP formulation may provide an alternative to conventional acellular vaccines to achieve a more balanced Th1/Th2 immune response.en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.rightsEmbargoed
dc.titlePLGA nano/micro particles encapsulated with pertussis toxoid (PTd) enhances Th1/Th17 immune response in a murine modelen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.description.statusPeer reviewed
dc.date.embargoedUntil2017-08-29
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pubmed/27586408
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2016-11-20
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ijpharm.2016.08.059
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.licenseref.startdate2017-08-29
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.date.embargo2017-08-29
herts.rights.accesstypeEmbargoed


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