| dc.contributor.author | Li, Pan | |
| dc.contributor.author | Asokanathanb, Catpagavalli | |
| dc.contributor.author | Liu, Fang | |
| dc.contributor.author | Khaing, Kyi Kyi | |
| dc.contributor.author | Kmiec, Dorota | |
| dc.contributor.author | Wei, Xiaoqing | |
| dc.contributor.author | Song, Bin | |
| dc.contributor.author | Xing, Dorothy | |
| dc.contributor.author | Kong, Deling | |
| dc.date.accessioned | 2018-01-30T22:12:16Z | |
| dc.date.available | 2018-01-30T22:12:16Z | |
| dc.date.issued | 2016-11-20 | |
| dc.identifier.citation | Li , P , Asokanathanb , C , Liu , F , Khaing , K K , Kmiec , D , Wei , X , Song , B , Xing , D & Kong , D 2016 , ' PLGA nano/micro particles encapsulated with pertussis toxoid (PTd) enhances Th1/Th17 immune response in a murine model ' , International Journal of Pharmaceutics , vol. 513 , no. 1-2 , pp. 183-190 . https://doi.org/10.1016/j.ijpharm.2016.08.059 | |
| dc.identifier.issn | 0378-5173 | |
| dc.identifier.uri | http://hdl.handle.net/2299/19639 | |
| dc.description | This document is the Accepted Manuscript version of the following article: Pan Li, Catpagavalli Asokanathan, Fang Liu, Kyi Kyi Khaing, Dorota Kmiec, Xiaoqing Wei, Sing Song, Dorothy Xing, and Deling Kong, ‘PLGA nano/micro particles encapsulated with pertussis toxoid (PTd) enhances Th1/Th17 immune response in a murine model’, International Journal of Pharmaceutics, Vol. 513 (1-2): 183-190, November 2016, available online at: https://doi.org/10.1016/j.ijpharm.2016.08.059. This manuscript version is made available under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives LicenseCC BY NC-ND 4.0 ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. | |
| dc.description.abstract | Poly(lactic-co-glycolic acid) (PLGA) based nano/micro particles were investigated as a potential vaccine platform for pertussis antigen. Presentation of pertussis toxoid as nano/micro particles (NP/MP) gave similar antigen-specific IgG responses in mice compared to soluble antigen. Notably, in cell line based assays, it was found that PLGA based nano/micro particles enhanced the phagocytosis of fluorescent antigen-nano/micro particles by J774.2 murine monocyte/macrophage cells compared to soluble antigen. More importantly, when mice were immunised with the antigen-nano/micro particles they significantly increased antigen-specific Th1 cytokines INF-γ and IL-17 secretion in splenocytes after in vitro re-stimulation with heat killed Bordetalla pertussis, indicating the induction of a Th1/Th17 response. Also, presentation of pertussis antigen in a NP/MP formulation is able to provide protection against respiratory infection in a murine model. Thus, the NP/MP formulation may provide an alternative to conventional acellular vaccines to achieve a more balanced Th1/Th2 immune response. | en |
| dc.format.extent | 8 | |
| dc.format.extent | 933047 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | International Journal of Pharmaceutics | |
| dc.title | PLGA nano/micro particles encapsulated with pertussis toxoid (PTd) enhances Th1/Th17 immune response in a murine model | en |
| dc.contributor.institution | School of Life and Medical Sciences | |
| dc.contributor.institution | Department of Pharmacy, Pharmacology and Postgraduate Medicine | |
| dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
| dc.contributor.institution | Pharmaceutics | |
| dc.contributor.institution | Pharmaceutical Analysis and Product Characterisation | |
| dc.contributor.institution | Bioadhesive Drug Delivery Group | |
| dc.description.status | Peer reviewed | |
| dc.date.embargoedUntil | 2017-08-29 | |
| dc.identifier.url | https://www.ncbi.nlm.nih.gov/pubmed/27586408 | |
| rioxxterms.versionofrecord | 10.1016/j.ijpharm.2016.08.059 | |
| rioxxterms.type | Journal Article/Review | |
| herts.preservation.rarelyaccessed | true | |
