dc.contributor.author | Furber, Matt | |
dc.contributor.author | Anton-Solanas, Ana | |
dc.contributor.author | Koppe, Emma | |
dc.contributor.author | Ashby, Charlotte | |
dc.contributor.author | Roberts, Michael | |
dc.contributor.author | Roberts, Justin | |
dc.date.accessioned | 2018-01-30T22:14:45Z | |
dc.date.available | 2018-01-30T22:14:45Z | |
dc.date.issued | 2017-08-31 | |
dc.identifier.citation | Furber , M , Anton-Solanas , A , Koppe , E , Ashby , C , Roberts , M & Roberts , J 2017 , ' A 7-day high protein hypocaloric diet promotes cellular metabolic adaptations and attenuates lean mass loss in healthy males ' , Clinical Nutrition Experimental , vol. 14 , pp. 13-25 . https://doi.org/10.1016/j.yclnex.2017.05.002 | |
dc.identifier.uri | http://hdl.handle.net/2299/19643 | |
dc.description | © 2017 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). | |
dc.description.abstract | Mitochondrial quantity and density are associated with increased oxidative metabolism. It has been demonstrated that a hypocaloric high fat/low carbohydrate (HF/LC) diet can up-regulate transcriptional markers of mitochondrial biogenesis; this was yet to be explored in vivo subsequent to a high protein/low carbohydrate (HP/LC) diet. Thus the aims of the study were to explore such diets on transcriptional markers or mitochondrial biogenesis, body composition and resting metabolic rate (RMR). Forty-five healthy male participants were randomly assigned one of four intervention diets: eucaloric high protein low carbohydrate (PRO-EM), hypocaloric high protein low carbohydrate (PRO-ER), eucaloric high carbohydrate (CHO-EM) or hypocaloric high carbohydrate (CHOER). The macronutrient ratio of the high protein diet and high carbohydrate diets was 40:30:30% and 10:60:30% (PRO:CHO:FAT) respectively. Energy intake for the hypocaloric diets were calculated to match resting metabolic rate. Participants visited the laboratory on 3 occasions each separated by 7 days. On each visit body composition, resting metabolic rate and a muscle biopsy from the vastus lateralis was collected. Prior to visit 1 and 2 habitual diet was consumed which was used as a control, between visit 2 and 3 the intervention diet was consumed continuously for 7-days. No group time effect was observed, however in the PRO-ER group a significant increase in AMPK, PGC-1a, SIRT1 and SIRT3 mRNA expression was observed post diet intervention groups (p < 0.05). No change was observed in any of the transcriptional markers in the other 3 groups. Despite ~30% reduction in calorie intake no difference in lean mass (LM) loss was observed between the PRO-ER and CHO-EM groups. The results from this study suggest that a 7-day a high protein low carbohydrate hypocaloric diet increased AMPK, SIRT1 and PGC-1 a mRNA expression at rest, and also suggest that increased dietary protein may attenuate LM mass loss in a hypocaloric state. | en |
dc.format.extent | 13 | |
dc.format.extent | 997589 | |
dc.language.iso | eng | |
dc.relation.ispartof | Clinical Nutrition Experimental | |
dc.subject | High protein diet | |
dc.subject | PGC-1a | |
dc.subject | AMPK | |
dc.subject | Hypocaloric | |
dc.subject | Low carbohydrate diet | |
dc.title | A 7-day high protein hypocaloric diet promotes cellular metabolic adaptations and attenuates lean mass loss in healthy males | en |
dc.contributor.institution | Department of Psychology and Sports Sciences | |
dc.contributor.institution | Agriculture, Food and Veterinary Sciences | |
dc.contributor.institution | Centre for Research in Psychology and Sport Sciences | |
dc.contributor.institution | Psychology of Movement | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Sport, Health and Exercise | |
dc.contributor.institution | Adaptive Physiology and Functional Nutrition | |
dc.contributor.institution | Health and Wellbeing | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1016/j.yclnex.2017.05.002 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |