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        Application of sebomics for the analysis of residual skin surface components to detect potential biomarkers of type-1 diabetes mellitus

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        Author
        Shetage, Satyajit S
        Traynor, Matthew J
        Brown, Marc B
        Galliford, Thomas M
        Chilcott, Robert P
        Attention
        2299/19713
        Abstract
        Metabolic imbalance in chronic diseases such as type-1 diabetes may lead to detectable perturbations in the molecular composition of residual skin surface components (RSSC). This study compared the accumulation rate and the composition of RSSC in type-1 diabetic patients with those in matched controls in order to identify potential biomarkers of the disease. Samples of RSSC were collected from the foreheads of type-1 diabetic (n = 55) and non-diabetic (n = 58) volunteers. Samples were subsequently analysed to identify individual components (sebomic analysis). There was no significant difference in the rate of accumulation of RSSC between type-1 diabetics and controls. In terms of molecular composition, 171 RSSC components were common to both groups, 27 were more common in non-diabetics and 18 were more common in type-1 diabetic patients. Statistically significant (P < 0.05) differences between diabetic and non-diabetic volunteers were observed in the recovered amounts of one diacylglyceride (m/z 594), six triacylglycerides (m/z 726-860) and six free fatty acids (m/z 271-345). These findings indicate that sebomic analysis can identify differences in the molecular composition of RSSC components between type-1 diabetic and non-diabetic individuals. Further work is required to determine the practical utility and identity of these potential biomarkers.
        Publication date
        2017-08-21
        Published in
        Scientific Reports
        Published version
        https://doi.org/10.1038/s41598-017-09014-6
        Other links
        http://hdl.handle.net/2299/19713
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