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        Evaluation of the ability of a novel miconazole formulation to penetrate nail by using three in vitro nail models

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        Accepted_Manuscript.pdf (PDF, 736Kb)
        Author
        Christensen, Luisa
        Turner, Rob
        Weaver, Sean
        Caserta, Francesco
        Long, Lisa
        Ghannoum, Mahmoud
        Brown, Marc
        Attention
        2299/19716
        Abstract
        In an effort to increase the efficacy of topical medications for treating onychomycosis, several new nail penetration enhancers were recently developed. In this study, the ability of 10% (wt/wt) miconazole nitrate combined with a penetration enhancer formulation to permeate the nail is demonstrated by the use of a selection of in vitro nail penetration assays. These assays included the bovine hoof, TurChub zone of inhibition, and infected-nail models.
        Publication date
        2017-07-01
        Published in
        Antimicrobial Agents and Chemotherapy
        Published version
        https://doi.org/10.1128/AAC.02554-16
        Other links
        http://hdl.handle.net/2299/19716
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