Evaluation of the ability of a novel miconazole formulation to penetrate nail by using three in vitro nail models

Christensen, Luisa, Turner, Rob, Weaver, Sean, Caserta, Francesco, Long, Lisa, Ghannoum, Mahmoud and Brown, Marc (2017) Evaluation of the ability of a novel miconazole formulation to penetrate nail by using three in vitro nail models. Antimicrobial Agents and Chemotherapy, 61 (7): e02554-16. ISSN 0066-4804

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In an effort to increase the efficacy of topical medications for treating onychomycosis, several new nail penetration enhancers were recently developed. In this study, the ability of 10% (wt/wt) miconazole nitrate combined with a penetration enhancer formulation to permeate the nail is demonstrated by the use of a selection of in vitro nail penetration assays. These assays included the bovine hoof, TurChub zone of inhibition, and infected-nail models.

Item Type	Article
Additional information	This document is the Accepted Manuscript of the following article: Luisa Christensen, Rob Turner, Sean Weaver, Francesco Caserta, Lisa Long, Mahmoud Ghannoum, and Marc Brown, ‘Evaluation of the Ability of a Novel Miconazole Formulation To Penetrate Nail by Using Three In Vitro Nail Models’, Antimicrobial Agents and Chemotherapy, Vol. 61 (7): e02554-16, July 2017. The final, published version is available online at DOI: https://doi.org/10.1128/AAC.02554-16.
Keywords	miconazole, onychomycosis, topical, pharmacology, pharmacology (medical), infectious diseases
Date Deposited	15 May 2025 13:43
Last Modified	02 Jul 2025 00:03