dc.contributor.author | Soares, M | |
dc.contributor.author | Toffart, A-C | |
dc.contributor.author | Timsit, J-F | |
dc.contributor.author | Burghi, G | |
dc.contributor.author | Irrazábal, C | |
dc.contributor.author | Pattison, N | |
dc.contributor.author | Tobar, E | |
dc.contributor.author | Almeida, B F C | |
dc.contributor.author | Silva, U V A | |
dc.contributor.author | Azevedo, L C P | |
dc.contributor.author | Rabbat, A | |
dc.contributor.author | Lamer, C | |
dc.contributor.author | Parrot, A | |
dc.contributor.author | Souza-Dantas, V C | |
dc.contributor.author | Wallet, F | |
dc.contributor.author | Blot, F | |
dc.contributor.author | Bourdin, G | |
dc.contributor.author | Piras, C | |
dc.contributor.author | Delemazure, J | |
dc.contributor.author | Durand, M | |
dc.contributor.author | Tejera, D | |
dc.contributor.author | Salluh, J I F | |
dc.contributor.author | Azoulay, E | |
dc.contributor.author | Lung Cancer in Critical Care (LUCCA) Study Investigators | |
dc.date.accessioned | 2018-02-12T18:07:19Z | |
dc.date.available | 2018-02-12T18:07:19Z | |
dc.date.issued | 2014-09-01 | |
dc.identifier.citation | Soares , M , Toffart , A-C , Timsit , J-F , Burghi , G , Irrazábal , C , Pattison , N , Tobar , E , Almeida , B F C , Silva , U V A , Azevedo , L C P , Rabbat , A , Lamer , C , Parrot , A , Souza-Dantas , V C , Wallet , F , Blot , F , Bourdin , G , Piras , C , Delemazure , J , Durand , M , Tejera , D , Salluh , J I F , Azoulay , E & Lung Cancer in Critical Care (LUCCA) Study Investigators 2014 , ' Intensive care in patients with lung cancer : a multinational study ' , Annals of Oncology , vol. 25 , no. 9 , pp. 1829-35 . https://doi.org/10.1093/annonc/mdu234 | |
dc.identifier.issn | 0923-7534 | |
dc.identifier.other | ORCID: /0000-0002-6771-8733/work/62751775 | |
dc.identifier.uri | http://hdl.handle.net/2299/19772 | |
dc.description | This is a pre-copyedited, author-produced version of an article accepted for publication in Annals of Oncology following peer review. The version of record M. Soares, et al, 'Intensive care in patients with lung cancer: a multinational study', Annals of Oncology, Vol. 25 (9): 1829-1835, September 2014, is available online at https://doi.org/10.1093/annonc/mdu234. | |
dc.description.abstract | BACKGROUND: Detailed information about lung cancer patients requiring admission to intensive care units (ICUs) is mostly restricted to single-center studies. Our aim was to evaluate the clinical characteristics and outcomes of lung cancer patients admitted to ICUs. PATIENTS AND METHODS: Prospective multicenter study in 449 patients with lung cancer (small cell, n = 55; non-small cell, n = 394) admitted to 22 ICUs in six countries in Europe and South America during 2011. Multivariate Cox proportional hazards frailty models were built to identify characteristics associated with 30-day and 6-month mortality. RESULTS: Most of the patients (71%) had newly diagnosed cancer. Cancer-related complications occurred in 56% of patients; the most common was tumoral airway involvement (26%). Ventilatory support was required in 53% of patients. Overall hospital, 30-day, and 6-month mortality rates were 39%, 41%, and 55%, respectively. After adjustment for type of admission and early treatment-limitation decisions, determinants of mortality were organ dysfunction severity, poor performance status (PS), recurrent/progressive cancer, and cancer-related complications. Mortality rates were far lower in the patient subset with nonrecurrent/progressive cancer and a good PS, even those with sepsis, multiple organ dysfunctions, and need for ventilatory support. Mortality was also lower in high-volume centers. Poor PS predicted failure to receive the initially planned cancer treatment after hospital discharge. CONCLUSIONS: ICU admission was associated with meaningful survival in lung cancer patients with good PS and non-recurrent/progressive disease. Conversely, mortality rates were very high in patients not fit for anticancer treatment and poor PS. In this subgroup, palliative care may be the best option. | en |
dc.format.extent | 7 | |
dc.format.extent | 954003 | |
dc.language.iso | eng | |
dc.relation.ispartof | Annals of Oncology | |
dc.subject | Carcinoma, Non-Small-Cell Lung | |
dc.subject | Cohort Studies | |
dc.subject | Critical Care | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Lung | |
dc.subject | Lung Neoplasms | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Prospective Studies | |
dc.subject | Severity of Illness Index | |
dc.subject | Treatment Outcome | |
dc.subject | Journal Article | |
dc.subject | Multicenter Study | |
dc.subject | Observational Study | |
dc.subject | Research Support, Non-U.S. Gov't | |
dc.title | Intensive care in patients with lung cancer : a multinational study | en |
dc.contributor.institution | School of Health and Social Work | |
dc.contributor.institution | Department of Adult Nursing and Primary Care | |
dc.contributor.institution | Centre for Applied Clinical, Health and Care Research (CACHE) | |
dc.contributor.institution | Centre for Future Societies Research | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1093/annonc/mdu234 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |