Show simple item record

dc.contributor.authorSoares, M
dc.contributor.authorToffart, A-C
dc.contributor.authorTimsit, J-F
dc.contributor.authorBurghi, G
dc.contributor.authorIrrazábal, C
dc.contributor.authorPattison, N
dc.contributor.authorTobar, E
dc.contributor.authorAlmeida, B F C
dc.contributor.authorSilva, U V A
dc.contributor.authorAzevedo, L C P
dc.contributor.authorRabbat, A
dc.contributor.authorLamer, C
dc.contributor.authorParrot, A
dc.contributor.authorSouza-Dantas, V C
dc.contributor.authorWallet, F
dc.contributor.authorBlot, F
dc.contributor.authorBourdin, G
dc.contributor.authorPiras, C
dc.contributor.authorDelemazure, J
dc.contributor.authorDurand, M
dc.contributor.authorTejera, D
dc.contributor.authorSalluh, J I F
dc.contributor.authorAzoulay, E
dc.contributor.authorLung Cancer in Critical Care (LUCCA) Study Investigators
dc.date.accessioned2018-02-12T18:07:19Z
dc.date.available2018-02-12T18:07:19Z
dc.date.issued2014-09-01
dc.identifier.citationSoares , M , Toffart , A-C , Timsit , J-F , Burghi , G , Irrazábal , C , Pattison , N , Tobar , E , Almeida , B F C , Silva , U V A , Azevedo , L C P , Rabbat , A , Lamer , C , Parrot , A , Souza-Dantas , V C , Wallet , F , Blot , F , Bourdin , G , Piras , C , Delemazure , J , Durand , M , Tejera , D , Salluh , J I F , Azoulay , E & Lung Cancer in Critical Care (LUCCA) Study Investigators 2014 , ' Intensive care in patients with lung cancer : a multinational study ' Annals of Oncology , vol 25 , no. 9 , pp. 1829-35 . DOI: 10.1093/annonc/mdu234
dc.identifier.issn0923-7534
dc.identifier.otherPURE: 12903525
dc.identifier.otherPURE UUID: 550b6e7a-42d9-44e5-a3b6-ea4993c9c487
dc.identifier.otherPubMed: 24950981
dc.identifier.otherScopus: 84904821961
dc.identifier.urihttp://hdl.handle.net/2299/19772
dc.descriptionThis is a pre-copyedited, author-produced version of an article accepted for publication in Annals of Oncology following peer review. The version of record M. Soares, et al, 'Intensive care in patients with lung cancer: a multinational study', Annals of Oncology, Vol. 25 (9): 1829-1835, September 2014, is available online at https://doi.org/10.1093/annonc/mdu234.
dc.description.abstractBACKGROUND: Detailed information about lung cancer patients requiring admission to intensive care units (ICUs) is mostly restricted to single-center studies. Our aim was to evaluate the clinical characteristics and outcomes of lung cancer patients admitted to ICUs. PATIENTS AND METHODS: Prospective multicenter study in 449 patients with lung cancer (small cell, n = 55; non-small cell, n = 394) admitted to 22 ICUs in six countries in Europe and South America during 2011. Multivariate Cox proportional hazards frailty models were built to identify characteristics associated with 30-day and 6-month mortality. RESULTS: Most of the patients (71%) had newly diagnosed cancer. Cancer-related complications occurred in 56% of patients; the most common was tumoral airway involvement (26%). Ventilatory support was required in 53% of patients. Overall hospital, 30-day, and 6-month mortality rates were 39%, 41%, and 55%, respectively. After adjustment for type of admission and early treatment-limitation decisions, determinants of mortality were organ dysfunction severity, poor performance status (PS), recurrent/progressive cancer, and cancer-related complications. Mortality rates were far lower in the patient subset with nonrecurrent/progressive cancer and a good PS, even those with sepsis, multiple organ dysfunctions, and need for ventilatory support. Mortality was also lower in high-volume centers. Poor PS predicted failure to receive the initially planned cancer treatment after hospital discharge. CONCLUSIONS: ICU admission was associated with meaningful survival in lung cancer patients with good PS and non-recurrent/progressive disease. Conversely, mortality rates were very high in patients not fit for anticancer treatment and poor PS. In this subgroup, palliative care may be the best option.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofAnnals of Oncology
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.subjectCarcinoma, Non-Small-Cell Lung
dc.subjectCohort Studies
dc.subjectCritical Care
dc.subjectFemale
dc.subjectHumans
dc.subjectLung
dc.subjectLung Neoplasms
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectProspective Studies
dc.subjectSeverity of Illness Index
dc.subjectTreatment Outcome
dc.subjectJournal Article
dc.subjectMulticenter Study
dc.subjectObservational Study
dc.subjectResearch Support, Non-U.S. Gov't
dc.titleIntensive care in patients with lung cancer : a multinational studyen
dc.contributor.institutionDepartment of Adult Nursing and Primary Care
dc.contributor.institutionSchool of Health and Social Work
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Health and Social Work
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2014-06-16
rioxxterms.versionAM
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1093/annonc/mdu234
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record