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dc.contributor.authorMcFarland, Lynne Vernice
dc.contributor.authorOzen, Metehan
dc.contributor.authorDinleyici, Ener Cagri
dc.contributor.authorGoh, Shan
dc.date.accessioned2018-02-16T16:17:57Z
dc.date.available2018-02-16T16:17:57Z
dc.date.issued2016-03-21
dc.identifier.citationMcFarland , L V , Ozen , M , Dinleyici , E C & Goh , S 2016 , ' Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections ' , World journal of gastroenterology , vol. 22 , no. 11 , pp. 3078-104 . https://doi.org/10.3748/wjg.v22.i11.3078
dc.identifier.issn1007-9327
dc.identifier.otherPURE: 11775281
dc.identifier.otherPURE UUID: cb677e29-822d-4716-bf4a-a69a40d81a91
dc.identifier.otherPubMed: 27003987
dc.identifier.otherPubMedCentral: PMC4789985
dc.identifier.otherScopus: 84960911177
dc.identifier.urihttp://hdl.handle.net/2299/19785
dc.descriptionThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/4.0/.
dc.description.abstractAntibiotic-associated diarrhea (AAD) and Clostridium difficile infections (CDI) have been well studied for adult cases, but not as well in the pediatric population. Whether the disease process or response to treatments differs between pediatric and adult patients is an important clinical concern when following global guidelines based largely on adult patients. A systematic review of the literature using databases PubMed (June 3, 1978-2015) was conducted to compare AAD and CDI in pediatric and adult populations and determine significant differences and similarities that might impact clinical decisions. In general, pediatric AAD and CDI have a more rapid onset of symptoms, a shorter duration of disease and fewer CDI complications (required surgeries and extended hospitalizations) than in adults. Children experience more community-associated CDI and are associated with smaller outbreaks than adult cases of CDI. The ribotype NAP1/027/BI is more common in adults than children. Children and adults share some similar risk factors, but adults have more complex risk factor profiles associated with more co-morbidities, types of disruptive factors and a wider range of exposures to C. difficile in the healthcare environment. The treatment of pediatric and adult AAD is similar (discontinuing or switching the inciting antibiotic), but other treatment strategies for AAD have not been established. Pediatric CDI responds better to metronidazole, while adult CDI responds better to vancomycin. Recurrent CDI is not commonly reported for children. Prevention for both pediatric and adult AAD and CDI relies upon integrated infection control programs, antibiotic stewardship and may include the use of adjunctive probiotics. Clinical presentation of pediatric AAD and CDI are different than adult AAD and CDI symptoms. These differences should be taken into account when rating severity of disease and prescribing antibiotics.en
dc.format.extent27
dc.language.isoeng
dc.relation.ispartofWorld journal of gastroenterology
dc.rightsOpen
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAge Distribution
dc.subjectAge Factors
dc.subjectAged
dc.subjectAnti-Bacterial Agents
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectClostridium difficile
dc.subjectDiarrhea
dc.subjectEnterocolitis, Pseudomembranous
dc.subjectHumans
dc.subjectIncidence
dc.subjectInfant
dc.subjectMiddle Aged
dc.subjectRecurrence
dc.subjectRisk Factors
dc.subjectSeverity of Illness Index
dc.subjectTreatment Outcome
dc.subjectYoung Adult
dc.subjectComparative Study
dc.subjectJournal Article
dc.subjectReview
dc.titleComparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infectionsen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2016-03-21
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.3748/wjg.v22.i11.3078
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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