dc.contributor.author | Carpenter, Lewis | |
dc.contributor.author | Norton, Sam | |
dc.contributor.author | Nikiphorou, Elena | |
dc.contributor.author | Jayakumar, Keeranur | |
dc.contributor.author | McWilliams, Daniel F. | |
dc.contributor.author | Rennie, Kirsten L. | |
dc.contributor.author | Dixey, Josh | |
dc.contributor.author | Kiely, Patrick | |
dc.contributor.author | Walsh, David Andrew | |
dc.contributor.author | Young, Adam | |
dc.contributor.author | on behalf of the Early Rheumatoid Arthritis Study and the Early Rheumatoid Arthritis Network | |
dc.date.accessioned | 2018-02-16T16:19:41Z | |
dc.date.available | 2018-02-16T16:19:41Z | |
dc.date.issued | 2017-11-28 | |
dc.identifier.citation | Carpenter , L , Norton , S , Nikiphorou , E , Jayakumar , K , McWilliams , D F , Rennie , K L , Dixey , J , Kiely , P , Walsh , D A , Young , A & on behalf of the Early Rheumatoid Arthritis Study and the Early Rheumatoid Arthritis Network 2017 , ' Reductions in Radiographic Progression in Early Rheumatoid Arthritis Over Twenty-Five Years: Changing Contribution From Rheumatoid Factor in Two Multicenter UK Inception Cohorts ' , Arthritis Care and Research , vol. 69 , no. 12 , pp. 1809-1817 . https://doi.org/10.1002/acr.23217 | |
dc.identifier.issn | 2151-464X | |
dc.identifier.uri | http://hdl.handle.net/2299/19791 | |
dc.description | This is the peer reviewed version of the following article: Lewis Carpenter, et al, ‘Reductions in Radiographic Progression in Early Rheumatoid Arthritis Over Twenty-Five Years: Changing Contribution From Rheumatoid Factor in Two Multicenter UK Inception Cohorts’, Arthritis Care & Research, Vol. 69 (12): 1809-1817, December 2017, which has been published in final form at https://doi.org/10.1002/acr.23217. Under embargo until 6 Nov 2018 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |
dc.description.abstract | Objective: To assess the 5-year progression of erosions and joint space narrowing (JSN) and their associations with rheumatoid factor (RF) status in 2 large, multicenter, early rheumatoid arthritis cohorts, spanning 25 years. Methods: Radiographic joint damage was recorded using the Sharp/van der Heijde (SHS) method in the Early Rheumatoid Arthritis Study (ERAS), 1986–2001, and the Early Rheumatoid Arthritis Network (ERAN), 2002–2013. Mixed-effects negative binomial regression estimated changes in radiographic damage over 5 years, including erosions and JSN, separately. RF, along with age, sex, and baseline markers of disease activity were controlled for. Results: A total of 1,216 patients from ERAS and 446 from ERAN had radiographic data. Compared to ERAS, ERAN patients had a lower mean total SHS score at baseline (ERAN 6.2 versus ERAS 10.5; P < 0.001) and mean annual rate of change (ERAN 2.5 per year versus ERAS 6.9 per year; P < 0.001). Seventy-four percent of ERAS and 27% of ERAN patients progressed ≥5 units. Lower scores at baseline in ERAN were largely driven by reductions in JSN (ERAS 3.9 versus ERAN 1.2; P < 0.001), along with erosions (ERAS 1.9 versus ERAN 0.8; P < 0.001). RF was associated with greater progression in each cohort, but the absolute difference in mean annual rate of change for RF-positive patients was substantially higher for ERAS (RF positive 8.6 versus RF negative 5.1; P < 0.001), relative to ERAN (RF positive 2.0 versus RF negative 1.9; P = 0.855). Conclusion: Radiographic progression was shown to be significantly reduced between the 2 cohorts, and was associated with lower baseline damage and other factors, including changes in early disease-modifying antirheumatic drug use. The impact of RF status as a prognostic marker of clinically meaningful change in radiographic progression has markedly diminished in the context of more modern treatment. | en |
dc.format.extent | 9 | |
dc.format.extent | 650271 | |
dc.language.iso | eng | |
dc.relation.ispartof | Arthritis Care and Research | |
dc.subject | Rheumatology | |
dc.title | Reductions in Radiographic Progression in Early Rheumatoid Arthritis Over Twenty-Five Years: : Changing Contribution From Rheumatoid Factor in Two Multicenter UK Inception Cohorts | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | Basic and Clinical Science Unit | |
dc.description.status | Peer reviewed | |
dc.date.embargoedUntil | 2018-11-06 | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85032993985&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1002/acr.23217 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |