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dc.contributor.authorFotheringham, James
dc.contributor.authorFogarty, Damian G
dc.contributor.authorEl Nahas, Meguid
dc.contributor.authorCampbell, Michael J
dc.contributor.authorFarrington, Ken
dc.date.accessioned2018-05-17T15:38:18Z
dc.date.available2018-05-17T15:38:18Z
dc.date.issued2015-09-30
dc.identifier.citationFotheringham , J , Fogarty , D G , El Nahas , M , Campbell , M J & Farrington , K 2015 , ' The mortality and hospitalization rates associated with the long interdialytic gap in thrice-weekly hemodialysis patients ' , Kidney international , vol. 88 , no. 3 , pp. 569-75 . https://doi.org/10.1038/ki.2015.141
dc.identifier.issn0085-2538
dc.identifier.otherPURE: 13324467
dc.identifier.otherPURE UUID: eedfd483-32b7-44cd-9cab-c17d9bdb534b
dc.identifier.otherPubMed: 25970155
dc.identifier.otherScopus: 84940793056
dc.identifier.urihttp://hdl.handle.net/2299/20051
dc.description.abstractExcess mortality and hospitalization have been identified after the 2-day gap in thrice-weekly hemodialysis patients compared with 1-day intervals, although findings vary internationally. Here we aimed to identify factors associated with mortality and hospitalization events in England using an incident cohort of 5864 hemodialysis patients from years 2002 to 2006 inclusive in the UK Renal Registry linked to hospitalization data. Higher admission rates were seen after the 2-day gap irrespective of whether thrice-weekly dialysis sequence commenced on a Monday or Tuesday (2.4 per year after the 2-day gap vs. 1.4 for the rest of the week, rate ratio 1.7). The greatest differences in admission rates were seen in patients admitted with fluid overload or with conditions associated with a high risk of fluid overload. Increased mortality following the 2-day gap was similarly independent of session pattern (20.5 vs. 16.7 per 100 patient years, rate ratio 1.22), with these increases being driven by out-of-hospital death (rate ratio 1.59 vs. 1.06 for in-hospital death). Non-white patients had an overall survival advantage, with the increased mortality after the 2-day gap being found only in whites. Thus, fluid overload may increase the risk of hospital admission after the 2-day gap and that the increased out-of-hospital mortality may relate to a higher incidence of sudden death. Future work should focus on exploring interventions in these subgroups.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofKidney international
dc.subjectAdult
dc.subjectAged
dc.subjectCause of Death
dc.subjectEngland
dc.subjectFemale
dc.subjectHospital Mortality
dc.subjectHospitalization
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRegistries
dc.subjectRenal Dialysis
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.subjectSurvival Analysis
dc.subjectTime Factors
dc.subjectTreatment Outcome
dc.subjectWater-Electrolyte Balance
dc.subjectWater-Electrolyte Imbalance
dc.subjectJournal Article
dc.subjectResearch Support, Non-U.S. Gov't
dc.titleThe mortality and hospitalization rates associated with the long interdialytic gap in thrice-weekly hemodialysis patientsen
dc.contributor.institutionBasic and Clinical Science Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2015-09-30
rioxxterms.versionofrecordhttps://doi.org/10.1038/ki.2015.141
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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