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dc.contributor.authorda Silva, Jéssica Bassi
dc.contributor.authorFerreira, Sabrina Barbosa de Souza
dc.contributor.authorReis, Adriano Valim
dc.contributor.authorCook, Michael Thomas
dc.contributor.authorBruschi, Marcos Luciano
dc.date.accessioned2018-05-25T14:07:26Z
dc.date.available2018-05-25T14:07:26Z
dc.date.issued2018-03-01
dc.identifier.citationda Silva , J B , Ferreira , S B D S , Reis , A V , Cook , M T & Bruschi , M L 2018 , ' Assessing mucoadhesion in polymer gels : The effect of method type and instrument variables ' , Polymers , vol. 10 , no. 3 , 254 . https://doi.org/10.3390/polym10030254
dc.identifier.otherPURE: 13563492
dc.identifier.otherPURE UUID: e3fb3c82-a073-4fe9-af2d-6cce436ec57f
dc.identifier.otherScopus: 85042705936
dc.identifier.urihttp://hdl.handle.net/2299/20089
dc.descriptionThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.description.abstractThe process of mucoadhesion has been widely studied using a wide variety of methods, which are influenced by instrumental variables and experiment design, making the comparison between the results of different studies difficult. The aim of this work was to standardize the conditions of the detachment test and the rheological methods of mucoadhesion assessment for semisolids, and introduce a texture profile analysis (TPA) method. A factorial design was developed to suggest standard conditions for performing the detachment force method. To evaluate the method, binary polymeric systems were prepared containing poloxamer 407 and Carbopol 971P®, Carbopol 974P®, or Noveon® Polycarbophil. The mucoadhesion of systems was evaluated, and the reproducibility of these measurements investigated. This detachment force method was demonstrated to be reproduceable, and gave different adhesion when mucin disk or ex vivo oral mucosa was used. The factorial design demonstrated that all evaluated parameters had an effect on measurements of mucoadhesive force, but the same was not observed for the work of adhesion. It was suggested that the work of adhesion is a more appropriate metric for evaluating mucoadhesion. Oscillatory rheology was more capable of investigating adhesive interactions than flow rheology. TPA method was demonstrated to be reproducible and can evaluate the adhesiveness interaction parameter. This investigation demonstrates the need for standardized methods to evaluate mucoadhesion and makes suggestions for a standard study design.en
dc.language.isoeng
dc.relation.ispartofPolymers
dc.rightsOpen
dc.subjectDetachment force
dc.subjectPluronic f127
dc.subjectRheology
dc.subjectTexture profile analysis
dc.subjectThermogelling polymers
dc.subjectThermoresponsive polymers
dc.subjectChemistry(all)
dc.subjectPolymers and Plastics
dc.titleAssessing mucoadhesion in polymer gels : The effect of method type and instrument variablesen
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionUniversity of Hertfordshire
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85042705936&partnerID=8YFLogxK
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2018-03-01
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.3390/polym10030254
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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