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dc.contributor.authorRanmal, Sejal
dc.contributor.authorO’Brien, Fiona
dc.contributor.authorLopez, Felipe
dc.contributor.authorRuiz, Fabrice
dc.contributor.authorOrlu, Mine
dc.contributor.authorTuleu, Catherine
dc.contributor.authorWalsh, Jennifer
dc.contributor.authorLiu, Fang
dc.date.accessioned2018-06-06T17:09:50Z
dc.date.available2018-06-06T17:09:50Z
dc.date.issued2018-04-01
dc.identifier.citationRanmal , S , O’Brien , F , Lopez , F , Ruiz , F , Orlu , M , Tuleu , C , Walsh , J & Liu , F 2018 , ' Methodologies for Assessing the Acceptability of Oral Formulations among children and older adults: A Systematic Review ' , Drug Discovery Today , vol. 23 , no. 4 , pp. 830-847 . https://doi.org/10.1016/j.drudis.2018.01.038
dc.identifier.issn1359-6446
dc.identifier.otherPURE: 13572658
dc.identifier.otherPURE UUID: 39ad221d-8151-4b1e-8f15-202a8b92a47f
dc.identifier.otherScopus: 85042196828
dc.identifier.urihttp://hdl.handle.net/2299/20153
dc.descriptionThis is an open access article distributed under the terms and conditions of the Creative Commons Attribution NonCommercial-NoDerivatives 4.0 International CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.abstractAcceptability of medicinal products in children and older populations is pivotal in ensuring adherence and therapeutic outcomes. This review systematically identifies studies reporting on formulation aspects of oral medications that affect their acceptability in these patient groups. Particular emphasis is placed on the evaluation of the methodologies employed in the studies. Sixty-eight studies were included for analysis, with 51 (75%) in children and 17 (25%) in older populations. The studies evaluated a range of oral formulations; however, the methodologies used differ considerably in participants’ characteristics, study settings, tools, acceptability definitions and criteria. It is evident that there is a lack of standardisation in study design as well as the assessment methods used in assessing acceptability of medicines in children and older populations. This review presents a systematic analysis on methods employed for assessing acceptability of oral medicines in children and older adults, to provide insights and recommendations regarding the design of reliable instruments in future studies.en
dc.format.extent18
dc.language.isoeng
dc.relation.ispartofDrug Discovery Today
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.subjectPharmacology
dc.subjectDrug Discovery
dc.titleMethodologies for Assessing the Acceptability of Oral Formulations among children and older adults: A Systematic Reviewen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85042196828&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
rioxxterms.versionAM
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rioxxterms.versionofrecordhttps://doi.org/10.1016/j.drudis.2018.01.038
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeopenAccess


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