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dc.contributor.authorDinasarapu, Ashok Dinasarapu
dc.contributor.authorChandrasekhar, Anjana
dc.contributor.authorInal, Jameel
dc.contributor.authorSubramaniam, Shankar
dc.date.accessioned2018-07-31T13:02:38Z
dc.date.available2018-07-31T13:02:38Z
dc.date.issued2013-12-10
dc.identifier.citationDinasarapu , A D , Chandrasekhar , A , Inal , J & Subramaniam , S 2013 , ' Complement C2 ' , The AFCS-nature Molecule Pages . https://doi.org/10.6072/H0.MP.A004234.01
dc.identifier.issn1477-5921
dc.identifier.otherPURE: 13401135
dc.identifier.otherPURE UUID: 12cf95f2-a98d-4c64-bbff-5b8414238551
dc.identifier.urihttp://www.signaling-gateway.org/molecule/query;jsessionid=164dc5498bfdfb749991d2a84b7de6d78bc73d69c4cc3719f8f783fe72c02263?afcsid=A004234&type=abstract
dc.description.abstractComplement C2 is a single chain serum glycoprotein (110 kDa), which serves as the catalytic subunit of C3 and C5 convertases in the classical and lectin pathways. During complement activation, C2 is cleaved by classical (C1s) or lectin (MBL-associated serine protease-2; MASP-2) proteases into two fragments: C2b and C2a. C2a, a serine protease, in complex with C4b fragment of complement factor C4, generates the C3 (C4b2a) or C5 (C4b2a3b) convertase. C3 convertase is very short-lived and cleaves complement C3 into C3a and C3b fragments (selective cleavage of Arg-|-Ser bond in C3 alpha-chain). C3 convertase requires the presence of magnesium and decays over time at physiologic temperatures. However, continuous activation of complement pathways shifts the substrate preference from C3 to C5 by formation of C5 convertase (formed by addition of C3b fragment to C3 convertase i.e. C4b2a3b). C5 convertase cleaves complement C5 to become activated into C5a and C5b fragments (selective cleavage of Arg-|-Xaa bond in C5 alpha-chain) and by a series of additional steps, promotes lysis of bacteria and damaged cells by pore or membrane attack complex (MAC) formation. Deficiency of C2 has been reported to be associated with certain autoimmune diseases. Single nucleotide polymorphisms (SNPs) in the C2 gene have been associated with altered susceptibility to age-related macular degeneration.en
dc.language.isoeng
dc.relation.ispartofThe AFCS-nature Molecule Pages
dc.rightsOpen
dc.titleComplement C2en
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.contributor.institutionBiosciences Research Group
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.signaling-gateway.org/molecule/query;jsessionid=164dc5498bfdfb749991d2a84b7de6d78bc73d69c4cc3719f8f783fe72c02263?afcsid=A004234&type=abstract
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2013-12-10
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.6072/H0.MP.A004234.01
rioxxterms.licenseref.uriOther
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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