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dc.contributor.authorInal, Jameel
dc.contributor.authorKholia, Sharad
dc.date.accessioned2018-07-31T14:30:40Z
dc.date.available2018-07-31T14:30:40Z
dc.date.issued2012-09-13
dc.identifier.citationInal , J & Kholia , S 2012 , ' Human skeletal muscle derived microvesicles induce apoptosis in highly metastatic prostate cancer cells ' Microvesiculation and Disease, a Biochemical Society Focused Meeting , London , United Kingdom , 13/09/12 - 14/09/12 , .
dc.identifier.citationconference
dc.identifier.otherPURE: 13382499
dc.identifier.otherPURE UUID: dac8d2d3-dede-4f3e-8994-d61a42a941f8
dc.identifier.urihttp://hdl.handle.net/2299/20318
dc.description.abstractThe human skeletal muscle is a highly vascularised tissue that contributes approximately 40% of the total body mass. These two factors make it a prime target for secondary cancer metastases. Surprisingly, malignant cancers rarely metastasize to the skeletal muscle. Only 1.6% of all soft tissue sarcomas (muscle) examined are metastatic in origin. Various researchers over the years have therefore tried to elucidate the cellular and molecular mechanisms contributing to this rarity of secondary metastasis but they still remain obscure. Although some have postulated high levels of lactic acid or reported factors such as adenosine released by the skeletal muscle cell to create a toxic environment for secondary tumour development, the role of skeletal muscle microvesicles (MVs) on tumour cells is yet to be reported. In previous work we showed MVs capable of fusing with target cells. In this study, we show that MVs derived from human skeletal muscle cells (HSkMC) have a cytotoxic effect (inducing 30% apoptosis) upon interaction with highly metastatic prostate cancer cells (PC3M). We therefore postulate that HSkMC MVs and possibly exosomes may contain certain protein factor(s) that could be the cause of the cytotoxic effect observed on targeted tumour cells.en
dc.language.isoeng
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.titleHuman skeletal muscle derived microvesicles induce apoptosis in highly metastatic prostate cancer cellsen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.contributor.institutionBiosciences Research Group
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
rioxxterms.versionAM
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeopenAccess


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