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dc.contributor.authorDe Luca, Maria Antonietta
dc.contributor.authorDi Chiara, Gaetano
dc.contributor.authorCadoni, Cristina
dc.contributor.authorLecca, Daniele
dc.contributor.authorOrsolini, Laura
dc.contributor.authorPapanti, Duccio
dc.contributor.authorCorkery, John
dc.contributor.authorSchifano, Fabrizio
dc.date.accessioned2018-08-16T00:12:10Z
dc.date.available2018-08-16T00:12:10Z
dc.date.issued2017-04-13
dc.identifier.citationDe Luca , M A , Di Chiara , G , Cadoni , C , Lecca , D , Orsolini , L , Papanti , D , Corkery , J & Schifano , F 2017 , ' Cannabis; epidemiological, neurobiological and psychopathological issues: an update ' , CNS & Neurological Disorders - Drug Targets , vol. 16 . https://doi.org/10.2174/1871527316666170413113246
dc.identifier.issn1871-5273
dc.identifier.otherPURE: 11676313
dc.identifier.otherPURE UUID: 4722066a-c251-4586-888c-53c179d9801b
dc.identifier.otherScopus: 85028975728
dc.identifier.urihttp://hdl.handle.net/2299/20374
dc.descriptionThis document is the Accepted Manuscript version of the following article: Maria Antonietta De Luca, Gaetano Di Chiara, Cristina Cadoni, Daniele Lecca, Laura Orsolini, Duccio Papanti, John Corkery, Fabrizio Schifano, 'Cannabis; Epidemiological, Neurobiological and Psychopathological Issues: An Update', CNS & Neurological Disorders - Drug Targets, Vol. 16, 2017. The published manuscript is available at EurekaSelect via https://doi.org/10.2174/1871527316666170413113246. Published by Bentham Science.
dc.description.abstractCannabis is the illicit drug with both the largest current levels of consumption and the highest reported lifetime prevalence levels in the world. Across different countries, the prevalence of cannabis use varies according to the individual income, with the highest use being reported in North America, Australia and Europe. Despite its ‘soft drug’ reputation, cannabis misuse may be associated with several acute and chronic adverse effects. The present article aims at reviewing several papers on epidemiological, neurobiological and psychopathological aspects of the use of cannabis. The PubMed database was here examined in order to collect and discuss a range of identified papers. Cannabis intake usually starts during late adolescence/early adulthood (15-24 years) and drastically decreases in adulthood with the acquisition of working, familiar and social responsibilities. Clinical evidence supports the current socio-epidemiological alarm concerning the increased consumption among youngsters and the risks related to the onset of psychotic disorders. The mechanism of action of cannabis presents some analogies with other abused drugs, e.g. opiates. Furthermore, it has been well demonstrated that cannabis intake in adolescence may facilitate the transition to the use and/or abuse of other psychotropic drugs, hence properly being considered a ‘gateway drug’. Some considerations on synthetic cannabimimetics are provided here as well. In conclusion, the highest prevalence of cannabis use and the social perception of a relatively low associated risk are in contrast with current knowledge based on biological and clinical evidence. Indeed, there are concerns relating to cannabis intake association with detrimental effects on both cognitive impairment and mental health.en
dc.language.isoeng
dc.relation.ispartofCNS & Neurological Disorders - Drug Targets
dc.rightsEmbargoed
dc.subjectcannabis
dc.subjectΔ9-THC
dc.subjectaddiction
dc.subjectcannabimimetics
dc.subjectgateway hypothesis
dc.subjectdopamine
dc.subjectmedical marijuana
dc.titleCannabis; epidemiological, neurobiological and psychopathological issues: an updateen
dc.contributor.institutionCentre for Clinical Practice, Safe Medicines and Drug Misuse Research
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionPsychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
dc.date.embargoedUntil2018-04-13
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2017-04-13
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.2174/1871527316666170413113246
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.licenseref.startdate2018-04-13
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.date.embargo2018-04-13
herts.rights.accesstypeEmbargoed


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