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dc.contributor.authorOozeer, Fazal
dc.contributor.authorYates, Laura
dc.contributor.authorDean, Charlotte
dc.contributor.authorFormstone, Caroline
dc.date.accessioned2018-08-16T00:12:25Z
dc.date.available2018-08-16T00:12:25Z
dc.date.issued2017-05-12
dc.identifier.citationOozeer , F , Yates , L , Dean , C & Formstone , C 2017 , ' A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin ' , Scientific Reports , vol. 7 , no. 1 , 1880 . https://doi.org/10.1038/s41598-017-01971-2
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 11767547
dc.identifier.otherPURE UUID: d919ed60-1717-4132-8852-35d5e7a4f2ed
dc.identifier.otherScopus: 85019211842
dc.identifier.urihttp://hdl.handle.net/2299/20376
dc.descriptionOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2017. Supplementary information accompanies this paper at doi:10.1038/s41598-017-01971-2.
dc.description.abstractThe question of how cell division orientation is determined is fundamentally important for understanding tissue and organ shape in both healthy or disease conditions. Here we provide evidence for cell contact-dependent orientation of planar cell division in the mammalian embryonic skin. We propose a model where the core planar polarity proteins Celsr1 and Frizzled-6 (Fz6) communicate the long axis orientation of interphase basal cells to neighbouring basal mitoses so that they align their horizontal division plane along the same axis. The underlying mechanism requires a direct, cell surface, planar polarised cue, which we posit depends upon variant post-translational forms of Celsr1 protein coupled to Fz6. Our hypothesis has parallels with contact-mediated division orientation in early C. elegans embryos suggesting functional conservation between the adhesion-GPCRs Celsr1 and Latrophilin-1. We propose that linking planar cell division plane with interphase neighbour long axis geometry reinforces axial bias in skin spreading around the mouse embryo body.en
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.rightsOpen
dc.subjectoriented cell division
dc.subjectskin
dc.subjectplanar cell polarity
dc.subjectMedicine(all)
dc.titleA role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skinen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.contributor.institutionBiosciences Research Group
dc.description.statusPeer reviewed
dc.identifier.urlhttp://rdcu.be/rXrZ
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2017-05-12
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1038/s41598-017-01971-2
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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