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dc.contributor.authorStyliari, Ioanna Danai
dc.contributor.authorConte, Claudia
dc.contributor.authorPearce, Amanda
dc.contributor.authorHuesler, Amanda
dc.contributor.authorCavanagh, Robert
dc.contributor.authorLimo, Marion
dc.contributor.authorGordhan, Dipak
dc.contributor.authorNieto-Orellana, Alejandro
dc.contributor.authorSuksiriworapong, Jiraphong
dc.contributor.authorCouturaud, Benoit
dc.contributor.authorWilliams, Phil
dc.contributor.authorHook, Andrew
dc.contributor.authorAlexander, Morgan R.
dc.contributor.authorGarnett, Martin
dc.contributor.authorAlexander, Cameron
dc.contributor.authorBurley, Jonathan
dc.contributor.authorTaresco, Vincenzo
dc.date.accessioned2018-08-16T00:17:25Z
dc.date.available2018-08-16T00:17:25Z
dc.date.issued2018-08-01
dc.identifier.citationStyliari , I D , Conte , C , Pearce , A , Huesler , A , Cavanagh , R , Limo , M , Gordhan , D , Nieto-Orellana , A , Suksiriworapong , J , Couturaud , B , Williams , P , Hook , A , Alexander , M R , Garnett , M , Alexander , C , Burley , J & Taresco , V 2018 , ' High‐Throughput Miniaturized Screening of Nanoparticle Formation via Inkjet Printing ' , Macromolecular Materials and Engineering , vol. 303 , no. 8 , 1800146 . https://doi.org/10.1002/mame.201800146
dc.identifier.issn1438-7492
dc.identifier.otherORCID: /0000-0002-7476-2994/work/53892676
dc.identifier.urihttp://hdl.handle.net/2299/20448
dc.descriptionThis is the peer reviewed version of the following article:Ioanna D. Styliari, et al, ‘High‐Throughput Miniaturized Screening of Nanoparticle Formation via Inkjet Printing’, Macromolecular Materials and Engineering, (2018), which has been published in final form at https://doi.org/10.1002/mame.201800146. Under embargo until 27 May 2019. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.description.abstractThe self‐assembly of specific polymers into well‐defined nanoparticles (NPs) is of great interest to the pharmaceutical industry as the resultant materials can act as drug delivery vehicles. In this work, a high‐throughput method to screen the ability of polymers to self‐assemble into NPs using a picoliter inkjet printer is presented. By dispensing polymer solutions in dimethyl sulfoxide (DMSO) from the printer into the wells of a 96‐well plate, containing water as an antisolvent, 50 suspensions are screened for nanoparticle formation rapidly using only nanoliters to microliters. A variety of polymer classes are used and in situ characterization of the submicroliter nanosuspensions shows that the particle size distributions match those of nanoparticles made from bulk suspensions. Dispensing organic polymer solutions into well plates via the printer is thus shown to be a reproducible and fast method for screening nanoparticle formation which uses two to three orders of magnitude less material than conventional techniques. Finally, a pilot study for a high‐throughput pipeline of nanoparticle production, physical property characterization, and cytocompatibility demonstrates the feasibility of the printing approach for screening of nanodrug delivery formulations. Nanoparticles are produced in the well plates, characterized for size and evaluated for effects on metabolic activity of lung cancer cells.en
dc.format.extent2869221
dc.language.isoeng
dc.relation.ispartofMacromolecular Materials and Engineering
dc.subjecthigh-throughput-miniaturized screening
dc.subjectinkjet printers
dc.subjectnanoparticles
dc.subjectself-assembling
dc.subjectGeneral Chemical Engineering
dc.subjectOrganic Chemistry
dc.subjectPolymers and Plastics
dc.subjectMaterials Chemistry
dc.titleHigh‐Throughput Miniaturized Screening of Nanoparticle Formation via Inkjet Printingen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.description.statusPeer reviewed
dc.date.embargoedUntil2019-05-27
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85047661012&partnerID=8YFLogxK
rioxxterms.versionofrecord10.1002/mame.201800146
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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