Show simple item record

Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2)

dc.contributor.authorUguru, Gabriel C
dc.contributor.authorMondhe, Madhav
dc.contributor.authorGoh, Shan
dc.contributor.authorHesketh, Andrew
dc.contributor.authorBibb, Mervyn J
dc.contributor.authorGood, Liam
dc.contributor.authorStach, James E M
dc.date.accessioned2018-09-12T15:20:08Z
dc.date.available2018-09-12T15:20:08Z
dc.date.issued2013-06-27
dc.identifier.citationUguru , G C , Mondhe , M , Goh , S , Hesketh , A , Bibb , M J , Good , L & Stach , J E M 2013 , ' Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2) ' , PLoS ONE , vol. 8 , no. 6 , pp. e67509 . https://doi.org/10.1371/journal.pone.0067509
dc.identifier.issn1932-6203
dc.identifier.otherPubMedCentral: PMC3694883
dc.identifier.otherORCID: /0000-0002-9028-0303/work/62751712
dc.identifier.urihttp://hdl.handle.net/2299/20576
dc.description.abstractWe demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production. Synthetic RNA silencing was target-specific and is a new tool for gene regulation and metabolic engineering studies in Streptomyces.en
dc.format.extent3566859
dc.language.isoeng
dc.relation.ispartofPLoS ONE
dc.subjectJournal Article
dc.titleSynthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2)en
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionExtracellular Vesicle Research Unit
dc.contributor.institutionBiosciences Research Group
dc.contributor.institutionCentre for Research in Mechanisms of Disease and Drug Discovery
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionCentre for Agriculture, Food and Environmental Management Research
dc.description.statusPeer reviewed
rioxxterms.versionofrecord10.1371/journal.pone.0067509
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

Thumbnail
Name:
journal.pone.0067509.PDF
Size:
3.401Mb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record