Anti-CTLA-4 (CD 152) monoclonal antibody-induced autoimmune interstitial nephritis
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Author
Jolly, Elaine C
Clatworthy, Menna R
Lawrence, Christopher
Nathan, Paul D
Farrington, Ken
Attention
2299/20681
Abstract
Targeted immune-modulating agents are entering clinical practice in many specialties, providing novel therapeutic possibilities but introducing new potential toxicities. We present the first reported case, to our knowledge, of immune-mediated nephritis following the administration of Tremelimumab (CP-675, 206), an anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) monoclonal antibody. High-dose steroid therapy led to a rapid improvement in renal function, avoiding the need for renal replacement therapy.