dc.contributor.author | Salazar, Celia | |
dc.contributor.author | Ruiz-Hincapie, Paula | |
dc.contributor.author | Ruiz, Lina María | |
dc.date.accessioned | 2018-10-25T01:17:51Z | |
dc.date.available | 2018-10-25T01:17:51Z | |
dc.date.issued | 2018-09-29 | |
dc.identifier.citation | Salazar , C , Ruiz-Hincapie , P & Ruiz , L M 2018 , ' The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis ' , Cells , vol. 7 , no. 10 , 154 . https://doi.org/10.3390/cells7100154 | |
dc.identifier.uri | http://hdl.handle.net/2299/20753 | |
dc.description.abstract | PARKIN (E3 ubiquitin ligase PARK2), PINK1 (PTEN induced kinase 1) and DJ-1 (PARK7) are proteins involved in autosomal recessive parkinsonism, and carcinogenic processes. In damaged mitochondria, PINK1's importing into the inner mitochondrial membrane is prevented, PARKIN presents a partial mitochondrial localization at the outer mitochondrial membrane and DJ-1 relocates to mitochondria when oxidative stress increases. Depletion of these proteins result in abnormal mitochondrial morphology. PINK1, PARKIN, and DJ-1 participate in mitochondrial remodeling and actively regulate mitochondrial quality control. In this review, we highlight that PARKIN, PINK1, and DJ-1 should be regarded as having an important role in Cancer Biology. The STRING database and Gene Ontology (GO) enrichment analysis were performed to consolidate knowledge of well-known protein interactions for PINK1, PARKIN, and DJ-1 and envisage new ones. The enrichment analysis of KEGG pathways showed that the PINK1/PARKIN/DJ-1 network resulted in Parkinson disease as the main feature, while the protein DJ-1 showed enrichment in prostate cancer and p53 signaling pathway. Some predicted transcription factors regulating PINK1, PARK2 (PARKIN) and PARK7 (DJ-1) gene expression are related to cell cycle control. We can therefore suggest that the interplay among PINK1/PARKIN/DJ-1 network during mitochondrial quality control in cancer biology may occur at the transcriptional level. Further analysis, like a systems biology approach, will be helpful in the understanding of PINK1/PARKIN/DJ-1 network. | en |
dc.format.extent | 3501266 | |
dc.language.iso | eng | |
dc.relation.ispartof | Cells | |
dc.title | The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis | en |
dc.contributor.institution | School of Engineering and Technology | |
dc.contributor.institution | BioEngineering | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.3390/cells7100154 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |