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dc.contributor.authorMatar, Hazem
dc.contributor.authorAmer, Nevine
dc.contributor.authorKansagra, Sneha
dc.contributor.authorPinhal, Andreia
dc.contributor.authorThomas, Elliot
dc.contributor.authorTownend, Scott
dc.contributor.authorLarner, Joanne
dc.contributor.authorChilcott, Robert
dc.date.accessioned2018-11-17T02:15:12Z
dc.date.available2018-11-17T02:15:12Z
dc.date.issued2018-11-15
dc.identifier.citationMatar , H , Amer , N , Kansagra , S , Pinhal , A , Thomas , E , Townend , S , Larner , J & Chilcott , R 2018 , ' Hybrid in vitro diffusion cell for simultaneous evaluation of hair and skin decontamination: temporal distribution of chemical contaminants ' , Scientific Reports , vol. 8 , 16906 . https://doi.org/10.1038/s41598-018-35105-z
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 15674932
dc.identifier.otherPURE UUID: bbb3c68b-c2ef-4f9a-ace7-9b484d032301
dc.identifier.otherScopus: 85056626867
dc.identifier.urihttp://hdl.handle.net/2299/20802
dc.description.abstractMost casualty or personnel decontamination studies have focused on removing contaminants from the skin. However, scalp hair and underlying skin are the most likely areas of contamination following airborne exposure to chemicals. The aim of this study was to investigate the interactions of contaminants with scalp hair and underlying skin using a hybrid in vitro diffusion cell model. The in vitro hybrid test system comprised “curtains” of human hair mounted onto sections of excised porcine skin within a modified diffusion cell. The results demonstrated that hair substantially reduced underlying scalp skin contamination and that hair may provide a limited decontamination effect by removing contaminants from the skin surface. This hybrid test system may have application in the development of improved chemical incident response processes through the evaluation of various hair and skin decontamination strategies.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.subjectGeneral
dc.titleHybrid in vitro diffusion cell for simultaneous evaluation of hair and skin decontamination: temporal distribution of chemical contaminantsen
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionToxicology
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85056626867&partnerID=8YFLogxK
dc.identifier.urlhttps://www.nature.com/articles/s41598-018-35105-z
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1038/s41598-018-35105-z
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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