dc.contributor.author | Tutone, Marco | |
dc.contributor.author | Pecoraro, Beatrice | |
dc.contributor.author | Almerico, Anna Maria | |
dc.date.accessioned | 2018-11-21T12:39:21Z | |
dc.date.available | 2018-11-21T12:39:21Z | |
dc.date.issued | 2018-07-23 | |
dc.identifier.citation | Tutone , M , Pecoraro , B & Almerico , A M 2018 , ' Investigation on Quantitative Structure-Activity Relationships of 1,3,4 Oxadiazole Derivatives as Potential Telomerase Inhibitors ' , Current Drug Discovery Technologies . https://doi.org/10.2174/1570163815666180724113208 | |
dc.identifier.issn | 1570-1638 | |
dc.identifier.other | ORCID: /0000-0001-8591-8811/work/62751615 | |
dc.identifier.uri | http://hdl.handle.net/2299/20815 | |
dc.description | The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/164022/article, DOI : 10.2174/1570163815666180724113208. © 2018 Bentham Science | |
dc.description.abstract | A series of 1,3,4-oxadiazole derivatives with significant broad-spectrum anticancer activity against different cell lines, and demonstrated telomerase inhibition, was subjected to Quantitative Structure-Activity Relationships (QSAR) analysis. Validated models with high correlation coefficients were developed. The Multiple Linear Regression (MLR) models, by Ordinary Least Squares (OLS), showed good robustness and predictive capability, according to the Multi-Criteria Decision Making (MCDM = 0.8352), a technique that simultaneously enhances the performances of a certain number of criteria. The descriptors selected for the models, such as electrotopological state (E-state) descriptors, and extended topochemical atom (ETA) descriptors, showed the relevant chemical information contributing to the activity of these compounds. The results obtained in this study make sure about the identification of potential hits as prospective telomerase inhibitors. | en |
dc.format.extent | 321481 | |
dc.language.iso | eng | |
dc.relation.ispartof | Current Drug Discovery Technologies | |
dc.subject | QSAR | |
dc.subject | 1,2,4-oxadiazoles | |
dc.subject | telomerase | |
dc.subject | antitumoral | |
dc.subject | Drug Discovery | |
dc.title | Investigation on Quantitative Structure-Activity Relationships of 1,3,4 Oxadiazole Derivatives as Potential Telomerase Inhibitors | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Clinical and Pharmaceutical Sciences | |
dc.description.status | Peer reviewed | |
dc.date.embargoedUntil | 2019-07-23 | |
rioxxterms.versionofrecord | 10.2174/1570163815666180724113208 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |