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dc.contributor.authorTutone, Marco
dc.contributor.authorPecoraro, Beatrice
dc.contributor.authorAlmerico, Anna Maria
dc.date.accessioned2018-11-21T12:39:21Z
dc.date.available2018-11-21T12:39:21Z
dc.date.issued2018-07-23
dc.identifier.citationTutone , M , Pecoraro , B & Almerico , A M 2018 , ' Investigation on Quantitative Structure-Activity Relationships of 1,3,4 Oxadiazole Derivatives as Potential Telomerase Inhibitors ' , Current drug discovery technologies . https://doi.org/10.2174/1570163815666180724113208
dc.identifier.issn1570-1638
dc.identifier.otherPURE: 15693047
dc.identifier.otherPURE UUID: 6d963c21-a77a-4934-b5e1-c616e4fdae67
dc.identifier.otherPubMed: 30039762
dc.identifier.otherORCID: /0000-0001-8591-8811/work/62751615
dc.identifier.otherScopus: 85061529388
dc.identifier.urihttp://hdl.handle.net/2299/20815
dc.descriptionThe published manuscript is available at EurekaSelect via http://www.eurekaselect.com/164022/article, DOI : 10.2174/1570163815666180724113208. © 2018 Bentham Science
dc.description.abstractA series of 1,3,4-oxadiazole derivatives with significant broad-spectrum anticancer activity against different cell lines, and demonstrated telomerase inhibition, was subjected to Quantitative Structure-Activity Relationships (QSAR) analysis. Validated models with high correlation coefficients were developed. The Multiple Linear Regression (MLR) models, by Ordinary Least Squares (OLS), showed good robustness and predictive capability, according to the Multi-Criteria Decision Making (MCDM = 0.8352), a technique that simultaneously enhances the performances of a certain number of criteria. The descriptors selected for the models, such as electrotopological state (E-state) descriptors, and extended topochemical atom (ETA) descriptors, showed the relevant chemical information contributing to the activity of these compounds. The results obtained in this study make sure about the identification of potential hits as prospective telomerase inhibitors.en
dc.language.isoeng
dc.relation.ispartofCurrent drug discovery technologies
dc.subjectQSAR
dc.subject1,2,4-oxadiazoles
dc.subjecttelomerase
dc.subjectantitumoral
dc.subjectDrug Discovery
dc.titleInvestigation on Quantitative Structure-Activity Relationships of 1,3,4 Oxadiazole Derivatives as Potential Telomerase Inhibitorsen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.description.statusPeer reviewed
dc.date.embargoedUntil2019-07-23
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.2174/1570163815666180724113208
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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