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dc.contributor.authorBarth, C
dc.contributor.authorSoares, M
dc.contributor.authorToffart, A C
dc.contributor.authorTimsit, J F
dc.contributor.authorBurghi, G
dc.contributor.authorIrrazabal, C
dc.contributor.authorPattison, N
dc.contributor.authorTobar, E
dc.contributor.authorAlmeida, B F
dc.contributor.authorSilva, U V
dc.contributor.authorAzevedo, L C
dc.contributor.authorRabbat, A
dc.contributor.authorLamer, C
dc.contributor.authorParrot, A
dc.contributor.authorSouza-Dantas, V C
dc.contributor.authorWallet, F
dc.contributor.authorBlot, F
dc.contributor.authorBourdin, G
dc.contributor.authorPiras, C
dc.contributor.authorDelemazure, J
dc.contributor.authorDurand, M
dc.contributor.authorSalluh, J
dc.contributor.authorAzoulay, E
dc.contributor.authorLemiale, Virginie
dc.date.accessioned2018-11-27T02:10:40Z
dc.date.available2018-11-27T02:10:40Z
dc.date.issued2018-08-04
dc.identifier.citationLung Cancer in Critical Care (LUCCA) Study Investigators 2018 , ' Characteristics and outcome of patients with newly diagnosed advanced or metastatic lung cancer admitted to intensive care units (ICUs) ' , Annals of intensive care , vol. 8 , no. 1 , 80 . https://doi.org/10.1186/s13613-018-0426-2
dc.identifier.issn2110-5820
dc.identifier.otherPURE: 15718569
dc.identifier.otherPURE UUID: dd12067f-c2fb-4e74-b97a-731b77cb1f97
dc.identifier.otherPubMed: 30076547
dc.identifier.otherPubMedCentral: PMC6076209
dc.identifier.otherScopus: 85051208112
dc.identifier.otherORCID: /0000-0002-6771-8733/work/62751767
dc.identifier.urihttp://hdl.handle.net/2299/20820
dc.description.abstractBACKGROUND: Although patients with advanced or metastatic lung cancer have poor prognosis, admission to the ICU for management of life-threatening complications has increased over the years. Patients with newly diagnosed lung cancer appear as good candidates for ICU admission, but more robust information to assist decisions is lacking. The aim of our study was to evaluate the prognosis of newly diagnosed unresectable lung cancer patients. METHODS: A retrospective multicentric study analyzed the outcome of patients admitted to the ICU with a newly diagnosed lung cancer (diagnosis within the month) between 2010 and 2013. RESULTS: Out of the 100 patients, 30 had small cell lung cancer (SCLC) and 70 had non-small cell lung cancer. (Thirty patients had already been treated with oncologic treatments.) Mechanical ventilation (MV) was performed for 81 patients. Seventeen patients received emergency chemotherapy during their ICU stay. ICU, hospital, 3- and 6-month mortality were, respectively, 47, 60, 67 and 71%. Hospital mortality was 60% when invasive MV was used alone, 71% when MV and vasopressors were needed and 83% when MV, vasopressors and hemodialysis were required. In multivariate analysis, hospital mortality was associated with metastatic disease (OR 4.22 [1.4-12.4]; p = 0.008), need for invasive MV (OR 4.20 [1.11-16.2]; p = 0.030), while chemotherapy in ICU was associated with survival (OR 0.23, [0.07-0.81]; p = 0.020). CONCLUSION: This study shows that ICU management can be appropriate for selected newly diagnosed patients with advanced lung cancer, and chemotherapy might improve outcome for patients with SCLC admitted for cancer-related complications. Nevertheless, tumors' characteristics, numbers and types of organ dysfunction should be taken into account in the decisional process before admitting these patients in ICU.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofAnnals of intensive care
dc.rightsOpen
dc.subjectChemotherapy
dc.subjectIntensive care
dc.subjectLung cancer
dc.subjectMetastatic
dc.subjectOutcome
dc.subjectCritical Care and Intensive Care Medicine
dc.titleCharacteristics and outcome of patients with newly diagnosed advanced or metastatic lung cancer admitted to intensive care units (ICUs)en
dc.contributor.institutionSchool of Health and Social Work
dc.contributor.institutionDepartment of Adult Nursing and Primary Care
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85051208112&partnerID=8YFLogxK
dc.relation.schoolSchool of Health and Social Work
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2018-08-04
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1186/s13613-018-0426-2
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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