dc.contributor.author | Matar, Hazem | |
dc.contributor.author | Price, Shirley | |
dc.contributor.author | Chilcott, Robert | |
dc.date.accessioned | 2018-12-20T10:25:50Z | |
dc.date.available | 2018-12-20T10:25:50Z | |
dc.date.issued | 2019-02-01 | |
dc.identifier.citation | Matar , H , Price , S & Chilcott , R 2019 , ' Further studies of the efficacy of military, commercial and novel skin decontaminants against the chemical warfare agents sulphur mustard, soman and VX ' , Toxicology in Vitro , vol. 54 , pp. 263-268 . https://doi.org/10.1016/j.tiv.2018.10.008 | |
dc.identifier.issn | 0887-2333 | |
dc.identifier.uri | http://hdl.handle.net/2299/20883 | |
dc.description.abstract | Background/Aims: Following an incident involving toxic chemicals, deployment of countermeasures before the arrival of specialised services at the scene may provide a “therapeutic” window in which to mitigate skin absorption. Methods: Five potential candidates (itaconic acid, N,N′-methylenebisacrylamide, 2-trifluoromethylacrylic acid, fuller's earth and Fast-Act®) previously found effective against a simulant (methyl salicylate) were evaluated against a 10 μL droplet of 14C-sulphur mustard (HD), soman (GD) or VX applied to the surface of porcine skin mounted on static skin diffusion cells. Results: All the decontaminants applied to the skin 5 min post exposure achieved a marked reduction in the amount of 14C contaminant remaining within the skin at 24 h. Itaconic acid significantly (p <.05) reduced the amount of 14C-HD, GD and VX remaining in the skin at 24 h. Additionally, 2-trifluoromethylacrylic acid significantly reduced the amount of 14C-HD, whilst fuller's earth significantly reduced the amounts of 14C-HD and VX recovered within the skin at 24 h. Conclusion: All of the products evaluated in this study performed well in reducing the dermal absorption of all the chemical warfare agents tested. | en |
dc.format.extent | 6 | |
dc.format.extent | 1652926 | |
dc.language.iso | eng | |
dc.relation.ispartof | Toxicology in Vitro | |
dc.subject | Chemical warfare agent | |
dc.subject | Decontamination | |
dc.subject | Methyl salicylate | |
dc.subject | Percutaneous absorption | |
dc.subject | Skin | |
dc.subject | Soman | |
dc.subject | Sulphur mustard | |
dc.subject | VX | |
dc.subject | Toxicology | |
dc.title | Further studies of the efficacy of military, commercial and novel skin decontaminants against the chemical warfare agents sulphur mustard, soman and VX | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Toxicology | |
dc.contributor.institution | Pharmaceutics | |
dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
dc.contributor.institution | Centre for Applied Clinical, Health and Care Research (CACHE) | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85055338326&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1016/j.tiv.2018.10.008 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |