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dc.contributor.authorShetage, Satyajit
dc.contributor.authorTraynor, Matthew
dc.contributor.authorBrown, Marc
dc.contributor.authorChilcott, Robert
dc.date.accessioned2018-12-20T11:01:07Z
dc.date.available2018-12-20T11:01:07Z
dc.date.issued2018-08-21
dc.identifier.citationShetage , S , Traynor , M , Brown , M & Chilcott , R 2018 , ' Sebomic identification of sex- and ethnicity-specific variations in residual skin surface components (RSSC) for bio-monitoring or forensic applications ' , Lipids in Health and Disease , vol. 17 , no. 1 , 17 , pp. 194 . https://doi.org/10.1186/s12944-018-0844-z
dc.identifier.issn1476-511X
dc.identifier.otherPURE: 15204906
dc.identifier.otherPURE UUID: 847a36e0-6582-427b-bbbd-fc6abaf37481
dc.identifier.otherScopus: 85051852296
dc.identifier.urihttp://hdl.handle.net/2299/20888
dc.description.abstractBackground: “Residual skin surface components” (RSSC) is the collective term used for the superficial layer of sebum, residue of sweat, small quantities of intercellular lipids and components of natural moisturising factor present on the skin surface. Potential applications of RSSC include use as a sampling matrix for identifying biomarkers of disease, environmental exposure monitoring, and forensics (retrospective identification of exposure to toxic chemicals). However, it is essential to first define the composition of “normal” RSSC. Therefore, the aim of the current study was to characterise RSSC to determine commonalities and differences in RSSC composition in relation to sex and ethnicity. Methods: Samples of RSSC were acquired from volunteers using a previously validated method and analysed by high-pressure liquid chromatography–atmospheric pressure chemical ionisation–mass spectrometry (HPLC-APCI-MS). The resulting data underwent sebomic analysis. Results: The composition and abundance of RSSC components varied according to sex and ethnicity. The normalised abundance of free fatty acids, wax esters, diglycerides and triglycerides was significantly higher in males than females. Ethnicity-specific differences were observed in free fatty acids and a diglyceride. Conclusions: The HPLC-APCI-MS method developed in this study was successfully used to analyse the normal composition of RSSC. Compositional differences in the RSSC can be attributed to sex and ethnicity and may reflect underlying factors such as diet, hormonal levels and enzyme expression.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofLipids in Health and Disease
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.subjectEthnicity
dc.subjectFree fatty acids
dc.subjectHigh-pressure liquid chromatography-atmospheric pressure chemical ionisation-mass spectrometry
dc.subjectSebum
dc.subjectSex
dc.subjectSkin surface lipids
dc.subjectSqualene
dc.subjectSweat
dc.subjectTriglycerides
dc.subjectWax esters
dc.subjectHumans
dc.subjectSebum/metabolism
dc.subjectMale
dc.subjectChromatography, High Pressure Liquid
dc.subjectAtmospheric Pressure
dc.subjectYoung Adult
dc.subjectMass Spectrometry
dc.subjectAdult
dc.subjectFemale
dc.subjectForensic Medicine/methods
dc.subjectContinental Population Groups
dc.subjectLipogenesis
dc.subjectEnvironmental Monitoring/methods
dc.subjectSkin/metabolism
dc.subjectIons
dc.subjectBiochemistry, medical
dc.subjectEndocrinology
dc.subjectClinical Biochemistry
dc.subjectEndocrinology, Diabetes and Metabolism
dc.titleSebomic identification of sex- and ethnicity-specific variations in residual skin surface components (RSSC) for bio-monitoring or forensic applicationsen
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionToxicology
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionNanopharmaceutics
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.contributor.institutionAirway Group
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85051852296&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2018-08-07
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1186/s12944-018-0844-z
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeopenAccess


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