Show simple item record

dc.contributor.authorTack, Chris
dc.contributor.authorShorthouse, Faye
dc.contributor.authorKass, Lindsy
dc.date.accessioned2019-01-22T10:30:03Z
dc.date.available2019-01-22T10:30:03Z
dc.date.issued2018-05-01
dc.identifier.citationTack , C , Shorthouse , F & Kass , L 2018 , ' The Physiological Mechanisms of Effect of Vitamins and Amino Acids on Tendon and Muscle Healing: A Systematic Review ' , International Journal of sports nutrition and exercise metabolism , vol. 28 , no. 3 , pp. 294-311 . https://doi.org/10.1123/ijsnem.2017-0267
dc.identifier.otherPURE: 12839041
dc.identifier.otherPURE UUID: c9524017-88fb-401c-bf47-3864cdb42042
dc.identifier.otherScopus: 85048776016
dc.identifier.urihttp://hdl.handle.net/2299/20997
dc.description© 2018 Human Kinetics, Inc.
dc.description.abstractTo evaluate the current literature via systematic review to ascertain whether amino acids/vitamins provide any influence on musculotendinous healing and if so, by which physiological mechanisms. Methods: EBSCO, PubMed, ScienceDirect, Embase Classic/Embase, and MEDLINE were searched using terms including "vitamins," "amino acids," "healing," "muscle," and "tendon." The primary search had 479 citations, of which 466 were excluded predominantly due to nonrandomized design. Randomized human and animal studies investigating all supplement types/forms of administration were included. Critical appraisal of internal validity was assessed using the Cochrane risk of Bias Tool or the Systematic Review Centre for Laboratory Animal Experimentation Risk of Bias Tool for human and animal studies, respectively. Two reviewers performed duel data extraction. Results: Twelve studies met criteria for inclusion: eight examined tendon healing and four examined muscle healing. All studies used animal models, except two human trials using a combined integrator. Narrative synthesis was performed via content analysis of demonstrated statistically significant effects and thematic analysis of proposed physiological mechanisms of intervention. Vitamin C/taurine demonstrated indirect effects on tendon healing through antioxidant activity. Vitamin A/glycine showed direct effects on extracellular matrix tissue synthesis. Vitamin E shows an antiproliferative influence on collagen deposition. Leucine directly influences signaling pathways to promote muscle protein synthesis. Discussion: Preliminary evidence exists, demonstrating that vitamins and amino acids may facilitate multilevel changes in musculotendinous healing; however, recommendations on clinical utility should be made with caution. All animal studies and one human study showed high risk of bias with moderate interobserver agreement (k = 0.46). Currently, there is limited evidence to support the use of vitamins and amino acids for musculotendinous injury. Both high-quality animal experimentation of the proposed mechanisms confirming the physiological influence of supplementation and human studies evaluating effects on tissue morphology and biochemistry are required before practical application.en
dc.format.extent18
dc.language.isoeng
dc.relation.ispartofInternational Journal of sports nutrition and exercise metabolism
dc.rightsOpen
dc.subjectMusculoskeletal tissue
dc.subjectNutrition
dc.subjectRehabilitation
dc.subjectSupplementation
dc.subjectMedicine (miscellaneous)
dc.subjectOrthopedics and Sports Medicine
dc.subjectNutrition and Dietetics
dc.titleThe Physiological Mechanisms of Effect of Vitamins and Amino Acids on Tendon and Muscle Healing: A Systematic Reviewen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Psychology and Sports Sciences
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.contributor.institutionCentre for Research in Psychology and Sport Sciences
dc.contributor.institutionSport, Health and Exercise
dc.contributor.institutionAdaptive Physiology and Functional Nutrition
dc.contributor.institutionHealth and Wellbeing
dc.contributor.institutionWeight and Obesity Research Group
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85048776016&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2018-05-01
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1123/ijsnem.2017-0267
rioxxterms.licenseref.uriOther
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record