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dc.contributor.authorTew, Garry
dc.contributor.authorLeighton, Dean
dc.contributor.authorCarpenter, Roger
dc.contributor.authorAnderson, Simon
dc.contributor.authorLangmead, Louise
dc.contributor.authorRamage, John
dc.contributor.authorFaulkner, James
dc.contributor.authorColeman, Elizabeth
dc.contributor.authorFairhurst, Caroline
dc.contributor.authorSeed, Michael
dc.contributor.authorBottoms, Lindsay
dc.date.accessioned2019-02-05T16:15:02Z
dc.date.available2019-02-05T16:15:02Z
dc.date.issued2019-01-29
dc.identifier.citationTew , G , Leighton , D , Carpenter , R , Anderson , S , Langmead , L , Ramage , J , Faulkner , J , Coleman , E , Fairhurst , C , Seed , M & Bottoms , L 2019 , ' High-intensity interval training and moderate-intensity continuous training in adults with Crohn’s disease: a pilot randomised controlled trial ' , BMC Gastroenterology , vol. 19 , no. 1 , 19 . https://doi.org/10.1186/s12876-019-0936-x
dc.identifier.issn1471-230X
dc.identifier.otherORCID: /0000-0003-4632-3764/work/92337140
dc.identifier.urihttp://hdl.handle.net/2299/21031
dc.description.abstractBackground: This study assessed the feasibility and acceptability of two common types of exercise training—high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)—in adults with Crohn’s disease (CD). Methods: In this mixed-methods pilot trial, participants with quiescent or mildly-active CD were randomly assigned 1:1:1 to HIIT, MICT or usual care control, and followed up for 6 months. The HIIT and MICT groups were offered three exercise sessions per week for the first 12 weeks. Feasibility outcomes included rates of recruitment, retention, outcome completion, and exercise attendance. Data were collected on cardiorespiratory fitness (e.g., peak oxygen uptake), disease activity, fatigue, quality of life, adverse events, and intervention acceptability (via interviews). Results: Over 17 months, 53 patients were assessed for eligibility and 36 (68%) were randomised (47% male; mean age 36.9 [SD 11.2] years); 13 to HIIT, 12 to MICT, and 11 to control. The exercise session attendance rate was 62% for HIIT (288/465) and 75% for MICT (320/429), with 62% of HIIT participants (8/13) and 67% of MICT participants (8/12) completing at least 24 of 36 sessions. One participant was lost to follow-up. Outcome completion rates ranged from 89 to 97%. The mean increase in peak oxygen uptake, relative to control, was greater following HIIT than MICT (2.4 vs. 0.7 mL/kg/min). There were three non-serious exercise-related adverse events, and two exercise participants experienced disease relapse during follow-up. Conclusions: The findings support the feasibility and acceptability of the exercise programmes and trial procedures. A definitive trial is warranted. Physical exercise remains a potentially useful adjunct therapy in CD. [ID: ISRCTN13021107]en
dc.format.extent684426
dc.language.isoeng
dc.relation.ispartofBMC Gastroenterology
dc.subjectExercise therapy
dc.subjectInflammatory bowel disease
dc.subjectRandomised controlled trial
dc.subjectGastroenterology
dc.titleHigh-intensity interval training and moderate-intensity continuous training in adults with Crohn’s disease: a pilot randomised controlled trialen
dc.contributor.institutionCentre for Research in Psychology and Sport Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionCentre for Applied Clinical, Health and Care Research (CACHE)
dc.contributor.institutionCentre for Future Societies Research
dc.contributor.institutionDepartment of Psychology, Sport and Geography
dc.contributor.institutionHigh Performance Sport Research Group
dc.contributor.institutionExercise, Health and Wellbeing Research Group
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85060712380&partnerID=8YFLogxK
rioxxterms.versionofrecord10.1186/s12876-019-0936-x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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