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        Co-Culture of Keratinocyte-Staphylococcus aureus on Cu-Ag-Zn/CuO and Cu-Ag-W Nanoparticle Loaded Bacterial Cellulose:PMMA Bandages

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        Author
        Ren, Guogang
        Edirisinghe, Mohan
        Altun, Esra
        Aydogdu, Mehmet Onur
        Crabbe-Mann, Maram
        Ahmed, Jubair
        Attention
        2299/21034
        Abstract
        Pressurized gyration and its sister processes are novel methods to produce polymeric fibers. Potential applications for such fibers include wound dressings, tissue engineering scaffolds, and filters. This study reports on a pressurized gyration technique that employs pressured N2 gas to prepare biocompatible wound dressing bandages from bacterial cellulose and poly (methylmethacrylate) polymer blended with alloyed antimicrobial nanoparti-cles. Resulting bandages are manufactured with high product yield and char-acterized for their chemical, physical, and mechanical properties. Increased density in solutions with additional antimicrobial nanoparticles results in increased fiber diameters. Also, addition of antimicrobial nanoparticles enhances ultimate tensile strength and Young’s modulus of the bandages. Typical molecular bonding in the bandages is confirmed by Fourier-transform infrared spectroscopy, with peaks that have higher intensity and narrowing points being caused by additional antimicrobial nanoparticles. More so, the cellular response to the bandages and the accompanying antimicrobial activity are studied in detail by in vitro co-culture of Staphylococcus aureusand keratinocytes. Antimicrobial nanoparticle-loaded bandage samples show increased cell viability and bacteria inhibition during co-culture and are found to have a promising future as epidermal wound dressing materials.
        Publication date
        2019-01-01
        Published in
        Macromolecular Materials and Engineering
        Published version
        https://doi.org/10.1002/mame.201800537
        License
        http://creativecommons.org/licenses/by/4.0/
        Other links
        http://hdl.handle.net/2299/21034
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