Show simple item record

dc.contributor.authorSchifano, Fabrizio
dc.contributor.authorChiappini, Stephania
dc.contributor.authorCorkery, John
dc.contributor.authorGuirguis, Amira
dc.date.accessioned2019-02-13T16:15:15Z
dc.date.available2019-02-13T16:15:15Z
dc.date.issued2019-02-01
dc.identifier.citationSchifano , F , Chiappini , S , Corkery , J & Guirguis , A 2019 , ' Assessing the 2004-2018 fentanyl misusing issues reported to an international range of adverse reporting systems ' , Frontiers in Pharmacology , vol. 10 , no. FEB , 46 , pp. 1-10 . https://doi.org/10.3389/fphar.2019.00046
dc.identifier.issn1663-9812
dc.identifier.otherORCID: /0000-0001-8255-0660/work/62748688
dc.identifier.otherORCID: /0000-0002-3849-817X/work/62749091
dc.identifier.urihttp://hdl.handle.net/2299/21077
dc.description© 2019 Schifano, Chiappini, Corkery and Guirguis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Submitted 2 October 2018, Accepted 14 January 2019, published 1 February 2019.
dc.description.abstractObjective: A recent, global, increase in the use of opioids including the prescribing, highly potent, fentanyl has been recorded. Due its current popularity and the potential lethal consequences of its intake, we aimed here at analyzing the fentanyl misuse, abuse, dependence and withdrawal-related adverse drug reactions (ADRs) identified within the European Medicines Agency (EMA), the United Kingdom Yellow Card Scheme (YCS), and the United States Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) databases. Methods: Descriptive analysis of both ADRs and related cases. Results: The analysis of fentanyl-related misuse, abuse, dependence and withdrawal cases reported during years 2004-2018 to the EMA, the YCS, and the FAERS showed increasing levels overtime, specifically, EMA-related data presented two peaks (e.g., in 2008 and 2015), whilst the FAERS dataset was characterized by a dramatic increase of the ADRs collected over the last 18 months, and particularly from 2016. Some 127,313 ADRs (referring to n = 6,161 patients/single cases) related to fentanyl's misuse/abuse/dependence/withdrawal issues were reported to EMA, with 14,287 being judged by the reporter as "suspect." The most represented ADRs were: "drug dependence "(76.87%), "intentional product misuse" (13.06%), and "drug abuse" (7.45%). Most cases involved adult males and the concomitant use of other prescribing/illicit drugs. A range of idiosyncratic (i.e., ingestion/injection of transdermal patches' fentanyl) and very high-dosage intake cases were here identified. Significant numbers of cases required either a prolonged hospitalization (192/559 = 34.35%) or resulted in death (185/559 = 33.09%). Within the same time frame, YCS collected some 3,566 misuse/abuse/dependence/withdrawal ADRs, corresponding to 1,165 single patients/cases, with those most frequently reported being "withdrawal," "intentional product misuse," and "overdose" ADRs. Finally, FAERS identified a total of 19,145 misuse/abuse/dependence/withdrawal-related cases, being "overdose," withdrawal, and "drug use disorder/drug abuse/drug diversion" the most represented ADRs (respectively, 43.11, 20.80, and 20.29%). Conclusion: Fentanyl abuse may be considered a public health issue with significant implications for clinical practice. Spontaneous pharmacovigilance reporting systems should be considered for mapping new trends of drug abuse.en
dc.format.extent10
dc.format.extent433685
dc.language.isoeng
dc.relation.ispartofFrontiers in Pharmacology
dc.subjectOpioids
dc.subjectFentanyl
dc.subjectprescription drug misuse
dc.subjectopioid-related deaths
dc.subjectNew psychoactive substances
dc.subjectNPS
dc.subjectPrescription drug misuse
dc.subjectOpioid-related deaths
dc.subjectPharmacology (medical)
dc.subjectPharmacology
dc.titleAssessing the 2004-2018 fentanyl misusing issues reported to an international range of adverse reporting systemsen
dc.contributor.institutionCentre for Clinical Practice, Safe Medicines and Drug Misuse Research
dc.contributor.institutionPsychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85066807896&partnerID=8YFLogxK
rioxxterms.versionofrecord10.3389/fphar.2019.00046
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record