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dc.contributor.authorCatalani, Valeria
dc.contributor.authorPrilutskaya, Mariya
dc.contributor.authorAl-Imam, Ahmed
dc.contributor.authorMarrinan, Shanna
dc.contributor.authorElgharably, Yasmine
dc.contributor.authorZloh, Mire
dc.contributor.authorMartinotti, Giovanni
dc.contributor.authorChilcott, Robert
dc.contributor.authorCorazza, Ornella
dc.date.accessioned2019-02-21T15:01:19Z
dc.date.available2019-02-21T15:01:19Z
dc.date.issued2018-02-20
dc.identifier.citationCatalani , V , Prilutskaya , M , Al-Imam , A , Marrinan , S , Elgharably , Y , Zloh , M , Martinotti , G , Chilcott , R & Corazza , O 2018 , ' Octodrine: New Questions and Challenges in Sport Supplements ' , Brain Sciences , vol. 8 , no. 2 , 34 . https://doi.org/10.3390/brainsci8020034
dc.identifier.issn2076-3425
dc.identifier.otherPURE: 13452302
dc.identifier.otherPURE UUID: c72ab560-213b-4fe3-adbf-da0fe4e39cdc
dc.identifier.otherScopus: 85042263302
dc.identifier.urihttp://hdl.handle.net/2299/21141
dc.descriptionThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
dc.description.abstractBackground: Octodrine is the trade name for Dimethylhexylamine (DMHA), a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Originally developed as a nasal decongestant in the 1950’s, it has recently been re-introduced on the market as a pre-workout and ‘fat-burner’ product but its use remains unregulated. Our work provides the first observational cross-sectional analytic study on Octodrine as a new drug trend and its associated harms after a gap spanning seven decades. Methods: A comprehensive multilingual assessment of literature, websites, drug fora and other online resources was carried out with no time restriction in English, German, Russian and Arabic. Keywords included Octodrine’s synonyms and chemical isomers. Results: Only five relevant publications emerged from the literature search, with most of the available data on body building websites and fora. Since 2015, Octodrine has been advertised online as “the next big thing” and “the god of stimulants,” with captivating marketing strategies directed at athletes and a wider cohort of users. Reported side-effects include hypertension, dyspnoea and hyperthermia. Conclusions: The uncontrolled use of Octodrine, its physiological and psychoactive effects raise serious health implications with possible impact on athletes and doping practices. This new phenomenon needs to be thoroughly studied and monitored.en
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofBrain Sciences
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.subjectoctodrine
dc.subjectdimethylhexylamine
dc.subjectDMHA
dc.subjectambredin
dc.subjectfitness
dc.subjectnovel psychoactive substance
dc.subjectperformance and image-enhancing drugs
dc.subjectanti-obesity agents
dc.subjectweight loss
dc.titleOctodrine: New Questions and Challenges in Sport Supplementsen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionToxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionCentre for Clinical Practice, Safe Medicines and Drug Misuse Research
dc.contributor.institutionPsychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2018-02-17
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.3390/brainsci8020034
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.rights.accesstypeopenAccess


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