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dc.contributor.authorSan-Cristobal, Rodrigo
dc.contributor.authorNavas-Carretero, Santiago
dc.contributor.authorLivingstone, Katherine M
dc.contributor.authorCelis-Morales, Carlos
dc.contributor.authorMacready, Anna L
dc.contributor.authorFallaize, Rosalind
dc.contributor.authorO'Donovan, Clare B
dc.contributor.authorLambrinou, Christina P
dc.contributor.authorMoschonis, George
dc.contributor.authorMarsaux, Cyril F M
dc.contributor.authorManios, Yannis
dc.contributor.authorJarosz, Miroslaw
dc.contributor.authorDaniel, Hannelore
dc.contributor.authorGibney, Eileen R
dc.contributor.authorBrennan, Lorraine
dc.contributor.authorDrevon, Christian A
dc.contributor.authorGundersen, Thomas E
dc.contributor.authorGibney, Mike
dc.contributor.authorSaris, Wim H M
dc.contributor.authorLovegrove, Julie A
dc.contributor.authorGrimaldi, Keith
dc.contributor.authorParnell, Laurence D
dc.contributor.authorBouwman, Jildau
dc.contributor.authorVan Ommen, Ben
dc.contributor.authorMathers, John C
dc.contributor.authorMartinez, J Alfredo
dc.date.accessioned2019-03-14T15:32:52Z
dc.date.available2019-03-14T15:32:52Z
dc.date.issued2017-10-11
dc.identifier.citationSan-Cristobal , R , Navas-Carretero , S , Livingstone , K M , Celis-Morales , C , Macready , A L , Fallaize , R , O'Donovan , C B , Lambrinou , C P , Moschonis , G , Marsaux , C F M , Manios , Y , Jarosz , M , Daniel , H , Gibney , E R , Brennan , L , Drevon , C A , Gundersen , T E , Gibney , M , Saris , W H M , Lovegrove , J A , Grimaldi , K , Parnell , L D , Bouwman , J , Van Ommen , B , Mathers , J C & Martinez , J A 2017 , ' Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention : The Food4Me Study ' , Nutrients , vol. 9 , no. 10 , 1107 . https://doi.org/10.3390/nu9101107
dc.identifier.issn2072-6643
dc.identifier.otherPURE: 13065421
dc.identifier.otherPURE UUID: aefd895f-c188-4dcc-b1e7-9103f1e427f7
dc.identifier.otherPubMed: 29019927
dc.identifier.otherPubMedCentral: PMC5691723
dc.identifier.otherScopus: 85031276940
dc.identifier.urihttp://hdl.handle.net/2299/21189
dc.description© 2017 by the authors.
dc.description.abstractMediterranean Diet (MedDiet) adherence has been proven to produce numerous health benefits. In addition, nutrigenetic studies have explained some individual variations in the response to specific dietary patterns. The present research aimed to explore associations and potential interactions between MedDiet adherence and genetic background throughout the Food4Me web-based nutritional intervention. Dietary, anthropometrical and biochemical data from volunteers of the Food4Me study were collected at baseline and after 6 months. Several genetic variants related to metabolic risk features were also analysed. A Genetic Risk Score (GRS) was derived from risk alleles and a Mediterranean Diet Score (MDS), based on validated food intake data, was estimated. At baseline, there were no interactions between GRS and MDS categories for metabolic traits. Linear mixed model repeated measures analyses showed a significantly greater decrease in total cholesterol in participants with a low GRS after a 6-month period, compared to those with a high GRS. Meanwhile, a high baseline MDS was associated with greater decreases in Body Mass Index (BMI), waist circumference and glucose. There also was a significant interaction between GRS and the MedDiet after the follow-up period. Among subjects with a high GRS, those with a high MDS evidenced a highly significant reduction in total carotenoids, while among those with a low GRS, there was no difference associated with MDS levels. These results suggest that a higher MedDiet adherence induces beneficial effects on metabolic outcomes, which can be affected by the genetic background in some specific markers.en
dc.format.extent17
dc.language.isoeng
dc.relation.ispartofNutrients
dc.rightsOpen
dc.subjectJournal Article
dc.titleMediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention : The Food4Me Studyen
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.contributor.institutionWeight and Obesity Research Group
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.contributor.institutionFood Policy, Nutrition and Diet
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2017-10-11
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.3390/nu9101107
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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