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dc.contributor.authorSisa, Claudia
dc.contributor.authorKholia, Sharad
dc.contributor.authorNaylor, Jordan
dc.contributor.authorHerrera Sanchez, Maria Beatriz
dc.contributor.authorBruno, Stefania
dc.contributor.authorDeregibus, Maria Chaiara
dc.contributor.authorCamussi, Giovanni
dc.contributor.authorInal, Jameel
dc.contributor.authorLange, Sigrun
dc.contributor.authorHristova, Mariya
dc.date.accessioned2019-03-20T15:08:20Z
dc.date.available2019-03-20T15:08:20Z
dc.date.issued2019-03-19
dc.identifier.citationSisa , C , Kholia , S , Naylor , J , Herrera Sanchez , M B , Bruno , S , Deregibus , M C , Camussi , G , Inal , J , Lange , S & Hristova , M 2019 , ' Mesenchymal stromal cell derived extracellular vesicles reduce hypoxia-ischaemia induced perinatal injury ' , Frontiers in Physiology , vol. 10 , no. MAR , 282 , pp. 282 . https://doi.org/10.3389/fphys.2019.00282
dc.identifier.issn1664-462X
dc.identifier.otherPURE: 16470868
dc.identifier.otherPURE UUID: 661099a7-f388-4f6a-add2-927771e6d993
dc.identifier.otherScopus: 85066424357
dc.identifier.urihttp://hdl.handle.net/2299/21209
dc.description© 2019 Sisa, Kholia, Naylor, Herrera Sanchez, Bruno, Deregibus, Camussi, Inal, Lange and Hristova.
dc.description.abstractBackground: Neonatal hypoxic-ischemic (HI) insult is a leading cause of disability and death in newborns, with therapeutic hypothermia being the only currently available clinical intervention. Thus there is a great need for adjunct and novel treatments for enhanced or alternative post-HI neuroprotection. Extracellular vesicles (EVs) derived from mesenchymal stromal/stem cells (MSCs) have recently been shown to exhibit regenerative effects in various injury models. Here we present findings showing neuroprotective effects of MSC-derived EVs in the Rice-Vannucci model of severe HI-induced neonatal brain insult. Methods: Mesenchymal stromal/stem cell-derived EVs were applied intranasally immediately post HI-insult and behavioral outcomes were observed 48 h following MSC-EV treatment, as assessed by negative geotaxis. Brains were thereafter excised and assessed for changes in glial responses, cell death, and neuronal loss as markers of damage at 48 h post HI-insult. Results: Brains of the MSC-EV treated group showed a significant decrease in microglial activation, cell death, and percentage tissue volume loss in multiple brain regions, compared to the control-treated groups. Furthermore, negative geotaxis test showed improved behavioral outcomes at 48 h following MSC-EV treatment. Conclusion: Our findings highlight the clinical potential of using MSC-derived EVs following neonatal hypoxia-ischaemia.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofFrontiers in Physiology
dc.subjectMesenchymal Stem Cells
dc.subjectExtracellular vesicles (EVs)
dc.subjectPerinatal Brain Injury
dc.subjectIschaemia
dc.subjectNeuroprotection
dc.subjectExtracellular vesicles
dc.subjectHypoxia
dc.subjectMesenchymal stromal/stem cells
dc.subjectMicroglia
dc.subjectMedicine(all)
dc.subjectPhysiology (medical)
dc.subjectPhysiology
dc.titleMesenchymal stromal cell derived extracellular vesicles reduce hypoxia-ischaemia induced perinatal injuryen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.contributor.institutionBiosciences Research Group
dc.contributor.institutionExtracellular Vesicle Research Unit
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85066424357&partnerID=8YFLogxK
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.3389/fphys.2019.00282
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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