dc.contributor.author | Sisa, Claudia | |
dc.contributor.author | Kholia, Sharad | |
dc.contributor.author | Naylor, Jordan | |
dc.contributor.author | Herrera Sanchez, Maria Beatriz | |
dc.contributor.author | Bruno, Stefania | |
dc.contributor.author | Deregibus, Maria Chaiara | |
dc.contributor.author | Camussi, Giovanni | |
dc.contributor.author | Inal, Jameel | |
dc.contributor.author | Lange, Sigrun | |
dc.contributor.author | Hristova, Mariya | |
dc.date.accessioned | 2019-03-20T15:08:20Z | |
dc.date.available | 2019-03-20T15:08:20Z | |
dc.date.issued | 2019-03-19 | |
dc.identifier.citation | Sisa , C , Kholia , S , Naylor , J , Herrera Sanchez , M B , Bruno , S , Deregibus , M C , Camussi , G , Inal , J , Lange , S & Hristova , M 2019 , ' Mesenchymal stromal cell derived extracellular vesicles reduce hypoxia-ischaemia induced perinatal injury ' , Frontiers in Physiology , vol. 10 , no. MAR , 282 , pp. 282 . https://doi.org/10.3389/fphys.2019.00282 | |
dc.identifier.issn | 1664-042X | |
dc.identifier.uri | http://hdl.handle.net/2299/21209 | |
dc.description | © 2019 Sisa, Kholia, Naylor, Herrera Sanchez, Bruno, Deregibus, Camussi, Inal, Lange and Hristova. | |
dc.description.abstract | Background: Neonatal hypoxic-ischemic (HI) insult is a leading cause of disability and death in newborns, with therapeutic hypothermia being the only currently available clinical intervention. Thus there is a great need for adjunct and novel treatments for enhanced or alternative post-HI neuroprotection. Extracellular vesicles (EVs) derived from mesenchymal stromal/stem cells (MSCs) have recently been shown to exhibit regenerative effects in various injury models. Here we present findings showing neuroprotective effects of MSC-derived EVs in the Rice-Vannucci model of severe HI-induced neonatal brain insult. Methods: Mesenchymal stromal/stem cell-derived EVs were applied intranasally immediately post HI-insult and behavioral outcomes were observed 48 h following MSC-EV treatment, as assessed by negative geotaxis. Brains were thereafter excised and assessed for changes in glial responses, cell death, and neuronal loss as markers of damage at 48 h post HI-insult. Results: Brains of the MSC-EV treated group showed a significant decrease in microglial activation, cell death, and percentage tissue volume loss in multiple brain regions, compared to the control-treated groups. Furthermore, negative geotaxis test showed improved behavioral outcomes at 48 h following MSC-EV treatment. Conclusion: Our findings highlight the clinical potential of using MSC-derived EVs following neonatal hypoxia-ischaemia. | en |
dc.format.extent | 10 | |
dc.format.extent | 1829796 | |
dc.language.iso | eng | |
dc.relation.ispartof | Frontiers in Physiology | |
dc.subject | Mesenchymal Stem Cells | |
dc.subject | Extracellular vesicles (EVs) | |
dc.subject | Perinatal Brain Injury | |
dc.subject | Ischaemia | |
dc.subject | Neuroprotection | |
dc.subject | Extracellular vesicles | |
dc.subject | Hypoxia | |
dc.subject | Mesenchymal stromal/stem cells | |
dc.subject | Microglia | |
dc.subject | Medicine(all) | |
dc.subject | Physiology (medical) | |
dc.subject | Physiology | |
dc.title | Mesenchymal stromal cell derived extracellular vesicles reduce hypoxia-ischaemia induced perinatal injury | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Biological and Environmental Sciences | |
dc.contributor.institution | Biosciences Research Group | |
dc.contributor.institution | Extracellular Vesicle Research Unit | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85066424357&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.3389/fphys.2019.00282 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |