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dc.contributor.authorStyliari, Ioanna Danai
dc.contributor.authorMobli, Arian
dc.contributor.authorMurnane, Darragh
dc.date.accessioned2019-04-10T14:13:59Z
dc.date.available2019-04-10T14:13:59Z
dc.date.issued2018-12-14
dc.identifier.citationStyliari , I D , Mobli , A & Murnane , D 2018 , ' Physicochemical characterisation of inhalation grade lactose after the removal of intrinsic fines ' , Drug Delivery to the Lungs 2018 , Edinburgh , United Kingdom , 12/12/18 - 14/12/18 . < https://aerosol-soc.com/abstracts/physicochemical-characterisation-of-inhalation-grade-lactose-after-the-removal-of-intrinsic-fines/ >
dc.identifier.citationconference
dc.identifier.otherPURE: 16580954
dc.identifier.otherPURE UUID: 4c24adf1-443a-4b44-bb60-cac17c7eaa8d
dc.identifier.otherORCID: /0000-0002-7476-2994/work/62751563
dc.identifier.urihttp://hdl.handle.net/2299/21247
dc.description.abstractLactose is a common excipient in Dry Powder Inhaler (DPI) formulations, used as a carrier for the micronized drug particles. The presence of intrinsic lactose fines in the formulation influences its performance and their role and interactions between the lactose carrier and the micronized drug is still not fully understood. As a first step towards this investigation, “clean” lactose, with removed fines, was produced via wet decantation. Ethanol and isopropyl alcohol have been used in wet decantation, successfully removing lactose fines from the surface of the coarse particles. Differential Scanning Calorimetry (DSC) was employed to show that the powders maintained their crystalline character. Scanning Electron Microscopy (SEM) showed tomahawk-shaped particles in all the powders and some surface alteration occurring after decantation. An airflow titration method using laser diffraction (LDA) allowed the estimation of the removal of fines as well as the particle size distributions, while the non-polar and the polar components of the surface energy of the powders were calculated via Inverse Gas Chromatography-Surface Energy Analysis (iGC-SEA). As both solvents successfully removed fines, we propose the addition of isopropyl alcohol in the list of organic solvents suitable for this purpose.en
dc.language.isoeng
dc.titlePhysicochemical characterisation of inhalation grade lactose after the removal of intrinsic finesen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.contributor.institutionAirway Group
dc.contributor.institutionPharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.description.statusPeer reviewed
dc.identifier.urlhttps://aerosol-soc.com/events/ddl2018/
dc.identifier.urlhttps://aerosol-soc.com/abstracts/physicochemical-characterisation-of-inhalation-grade-lactose-after-the-removal-of-intrinsic-fines/
rioxxterms.versionVoR
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue


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