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dc.contributor.authorFederico, Concetta
dc.contributor.authorOwoka, Temitayo
dc.contributor.authorRagusa, Denise
dc.contributor.authorSturiale, Valentina
dc.contributor.authorCaponnetto, Domenica
dc.contributor.authorLeotta, Claudia Giovanna
dc.contributor.authorBruno, Francesca
dc.contributor.authorFoster, Helen
dc.contributor.authorRigamonti, Silvia
dc.contributor.authorGiudici, Giovanni
dc.contributor.authorCazzaniga, Giovanni
dc.contributor.authorBridger, Joanna
dc.contributor.authorSisu, Cristina
dc.contributor.authorSaccone, Salvatore
dc.contributor.authorTosi, Sabrina
dc.date.accessioned2019-04-26T14:04:54Z
dc.date.available2019-04-26T14:04:54Z
dc.date.issued2019-04-25
dc.identifier.citationFederico , C , Owoka , T , Ragusa , D , Sturiale , V , Caponnetto , D , Leotta , C G , Bruno , F , Foster , H , Rigamonti , S , Giudici , G , Cazzaniga , G , Bridger , J , Sisu , C , Saccone , S & Tosi , S 2019 , ' Deletions of Chromosome 7q Affect Nuclear Organization and HLXB9Gene Expression in Hematological Disorders. ' , Cancers , vol. 11 , no. 4 , 585 . https://doi.org/10.3390/cancers11040585
dc.identifier.issn2072-6694
dc.identifier.otherPURE: 16632635
dc.identifier.otherPURE UUID: 3a07617d-b8a4-4d4a-9423-e41f6977df83
dc.identifier.otherScopus: 85070880454
dc.identifier.otherORCID: /0000-0001-6553-4562/work/62751370
dc.identifier.urihttp://hdl.handle.net/2299/21303
dc.description© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractThe radial spatial positioning of individual gene loci within interphase nuclei has been associated with up- and downregulation of their expression. In cancer, the genome organization may become disturbed due to chromosomal abnormalities, such as translocations or deletions, resulting in the repositioning of genes and alteration of gene expression with oncogenic consequences. In this study, we analyzed the nuclear repositioning of HLXB9 (also called MNX1), mapping at 7q36.3, in patients with hematological disorders carrying interstitial deletions of 7q of various extents, with a distal breakpoint in 7q36. We observed that HLXB9 remains at the nuclear periphery, or is repositioned towards the nuclear interior, depending upon the compositional properties of the chromosomal regions involved in the rearrangement. For instance, a proximal breakpoint leading the guanine-cytosine (GC)-poor band 7q21 near 7q36 would bring HLXB9 to the nuclear periphery, whereas breakpoints that join the GC-rich band 7q22 to 7q36 would bring HLXB9 to the nuclear interior. This nuclear repositioning is associated with transcriptional changes, with HLXB9 in the nuclear interior becoming upregulated. Here we report an in cis rearrangement, involving one single chromosome altering gene behavior. Furthermore, we propose a mechanistic model for chromatin reorganization that affects gene expression via the influences of new chromatin neighborhoods.en
dc.format.extent19
dc.language.isoeng
dc.relation.ispartofCancers
dc.rightsOpen
dc.subjectChromosome 7
dc.subjectChromosome deletion
dc.subjectGenome organization
dc.subjectHLXB9 gene
dc.subjectLeukemia
dc.subjectMNX1 gene
dc.subjectRadial positioning
dc.subjectOncology
dc.subjectCancer Research
dc.titleDeletions of Chromosome 7q Affect Nuclear Organization and HLXB9Gene Expression in Hematological Disorders.en
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85070880454&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2019-04-25
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.3390/cancers11040585
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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