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dc.contributor.authorFineberg, Naomi
dc.contributor.authorDell'Osso, Bernardo
dc.contributor.authorAlbert, Umberto
dc.contributor.authorMaina, Giuseppe
dc.contributor.authorGeller, Daniel
dc.contributor.authorCarmi, Lior
dc.contributor.authorSireau, Nick
dc.contributor.authorWalitza, Susanne
dc.contributor.authorGrassi, Giacomo
dc.contributor.authorPallanti, Stefano
dc.contributor.authorHollander, Eric
dc.contributor.authorBrakoulias, Vlasios
dc.contributor.authorMenchon, Jose M.
dc.contributor.authorMarazziti, Donatella
dc.contributor.authorIoannidis, Konstantinos
dc.contributor.authorApergis-Schoute, Annemieke
dc.contributor.authorStein, Dan J.
dc.contributor.authorCath, Danielle C.
dc.contributor.authorVeltman, Dick J.
dc.contributor.authorVan Ameringen, Michael
dc.contributor.authorFontenelle, Leonardo F.
dc.contributor.authorShavitt, Roseli G.
dc.contributor.authorCosta, Daniel
dc.contributor.authorDiniz, Juliana B.
dc.contributor.authorZohar, Joseph
dc.date.accessioned2019-05-08T14:06:32Z
dc.date.available2019-05-08T14:06:32Z
dc.date.issued2019-04-01
dc.identifier.citationFineberg , N , Dell'Osso , B , Albert , U , Maina , G , Geller , D , Carmi , L , Sireau , N , Walitza , S , Grassi , G , Pallanti , S , Hollander , E , Brakoulias , V , Menchon , J M , Marazziti , D , Ioannidis , K , Apergis-Schoute , A , Stein , D J , Cath , D C , Veltman , D J , Van Ameringen , M , Fontenelle , L F , Shavitt , R G , Costa , D , Diniz , J B & Zohar , J 2019 , ' Early intervention for obsessive compulsive disorder : An expert consensus statement ' , European Neuropsychopharmacology , vol. 29 , no. 4 , pp. 549-565 . https://doi.org/10.1016/j.euroneuro.2019.02.002
dc.identifier.issn0924-977X
dc.identifier.otherPURE: 16664112
dc.identifier.otherPURE UUID: 0435bba4-9c7e-4403-a282-0f960c70c5fa
dc.identifier.otherScopus: 85061443166
dc.identifier.urihttp://hdl.handle.net/2299/21315
dc.description© 2019 Elsevier B.V.and ECNP. All rights reserved.
dc.description.abstractObsessive-compulsive disorder (OCD) is common, emerges early in life and tends to run a chronic, impairing course. Despite the availability of effective treatments, the duration of untreated illness (DUI) is high (up to around 10 years in adults) and is associated with considerable suffering for the individual and their families. This consensus statement represents the views of an international group of expert clinicians, including child and adult psychiatrists, psychologists and neuroscientists, working both in high and low and middle income countries, as well as those with the experience of living with OCD. The statement draws together evidence from epidemiological, clinical, health economic and brain imaging studies documenting the negative impact associated with treatment delay on clinical outcomes, and supporting the importance of early clinical intervention. It draws parallels between OCD and other disorders for which early intervention is recognized as beneficial, such as psychotic disorders and impulsive-compulsive disorders associated with problematic usage of the Internet, for which early intervention may prevent the development of later addictive disorders. It also generates new heuristics for exploring the brain-based mechanisms moderating the ‘toxic’ effect of an extended DUI in OCD. The statement concludes that there is a global unmet need for early intervention services for OC related disorders to reduce the unnecessary suffering and costly disability associated with under-treatment. New clinical staging models for OCD that may be used to facilitate primary, secondary and tertiary prevention within this context are proposed.en
dc.format.extent17
dc.language.isoeng
dc.relation.ispartofEuropean Neuropsychopharmacology
dc.rightsEmbargoed
dc.subjectCompulsive
dc.subjectDuration of untreated illness
dc.subjectEarly intervention
dc.subjectObsessive
dc.subjectOCD
dc.subjectStaging
dc.subjectPharmacology
dc.subjectNeurology
dc.subjectClinical Neurology
dc.subjectPsychiatry and Mental health
dc.subjectBiological Psychiatry
dc.subjectPharmacology (medical)
dc.titleEarly intervention for obsessive compulsive disorder : An expert consensus statementen
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
dc.date.embargoedUntil2020-02-14
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85061443166&partnerID=8YFLogxK
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2019-04-01
rioxxterms.versionAM
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.euroneuro.2019.02.002
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.licenseref.startdate2020-02-14
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.date.embargo2020-02-14
herts.rights.accesstypeEmbargoed


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