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        Paper and electronic versions of HM-PRO, a novel patient-reported outcome measure for hematology: an equivalence study.

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        Paper_and_electronic_versions_of_HM_PRO_a_novel_patient_reported_outcome_measure_for_hematology_an_equivalence_study.pdf (PDF, 1Mb)
        Author
        Goswami, Pushpendra
        Oliva, Esther
        Ionova, Tatyana
        Else, R
        Kell, J
        Fielding, AK
        Jennings, DM
        Karakantza , M
        Al-Ismail, S
        Lyness, J
        Collins, GP
        McConnell , S
        Langton, C
        Al-Obaidi, MJ
        Oblak, M
        Salek, Mir-Saeed Shayegan
        Attention
        2299/21319
        Abstract
        Aim:To determine measurement equivalence of paper and electronic application of the hematologi-cal malignancy-patient-reported outcome (HM-PRO), a specific measure for the evaluation of patient-reported outcomes in HMs.Patients & methods:Following International Society of Pharmacoeconomicsand Outcomes Research ePRO Good Research Practice Task Force guidelines, a total of 193 adult patientswith different HMs were recruited into a multicenter prospective study. The paper and the electronic ver-sion of the instrument were completed in the outpatient clinics in a randomized crossover design with a30-min time interval to minimize the learning effect. Those who completed the paper version first, com-pleted the electronic version after 30 min and vice versa. Instrument version and order effects were testedon total score of the two parts of the HM-PRO (Part A: quality of life and Part B: signs & symptoms) in atwo-way ANOVA with patients as random effects. Intraclass correlation coefficients (95% CI) and Spear-man’s rank correlation coefficients were used to evaluate test–retest reliability and reproducibility. Theeffects of instrument version and order were tested on total score of the two parts of HM-PRO.Results:The questionnaire version and administration order effects were not significant at the 5% level. Therewere no interactions found between these two factors for HM-PRO (Part A [quality of life]; p=0.95); and(part B [signs and symptoms]; p=0.72]. Spearman’s rank correlation coefficients were greater than 0.9, andintraclass correlation coefficients ranged from 0.94 to 0.98; furthermore, the scores were not statisticallydifferent between the two versions, showing acceptable reliability indexes. Noteworthy, the differencebetween the completion time for both paper (mean=6:38 min) and electronic version (mean=7:29 min)was not statistically significant (n=100; p=0.11). Patients did not report any difficulty in completing theelectronic version during cognitive interviews and were able to understand and respond spontaneously.Conclusion:Measurement equivalence has been demonstrated for the paper and electronic applicationof the HM-PRO.
        Publication date
        2019-04-30
        Published in
        Journal of Comparative Effectiveness Research
        Published version
        https://doi.org/10.2217/cer-2018-0108
        Other links
        http://hdl.handle.net/2299/21319
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