dc.contributor.author | Okafor, Osita N | |
dc.contributor.author | Gorog, Diana A | |
dc.date.accessioned | 2019-05-10T14:04:52Z | |
dc.date.available | 2019-05-10T14:04:52Z | |
dc.date.issued | 2015-04-28 | |
dc.identifier.citation | Okafor , O N & Gorog , D A 2015 , ' Endogenous Fibrinolysis : An Important Mediator of Thrombus Formation and Cardiovascular Risk ' , Journal of the American College of Cardiology , vol. 65 , no. 16 , pp. 1683-1699 . https://doi.org/10.1016/j.jacc.2015.02.040 | |
dc.identifier.issn | 0735-1097 | |
dc.identifier.uri | http://hdl.handle.net/2299/21326 | |
dc.description | © 2015 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION. PUBLISHED BY ELSEVIER INC. | |
dc.description.abstract | Most acute cardiovascular events are attributable to arterial thrombosis. Plaque rupture or erosion stimulates platelet activation, aggregation, and thrombosis, whilst simultaneously activating enzymatic processes that mediate endogenous fibrinolysis to physiologically maintain vessel patency. Interplay between these pathways determines clinical outcome. If proaggregatory factors predominate, the thrombus may propagate, leading to vessel occlusion. However, if balanced by a healthy fibrinolytic system, thrombosis may not occur or cause lasting occlusion. Despite abundant evidence for the fibrinolytic system regulating thrombosis, it has been overlooked compared with platelet reactivity, partly due to a lack of techniques to measure it. We evaluate evidence for endogenous fibrinolysis in arterial thrombosis and review techniques to assess it, including biomarkers and global assays, such as thromboelastography and the Global Thrombosis Test. Global assays, simultaneously assessing proaggregatory and fibrinolytic pathways, could play a role in risk stratification and in identifying impaired fibrinolysis as a potential target for pharmacological modulation. | en |
dc.format.extent | 2079111 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of the American College of Cardiology | |
dc.subject | Acute Coronary Syndrome | |
dc.subject | Biomarkers | |
dc.subject | Cardiovascular Diseases | |
dc.subject | Fibrinolysis | |
dc.subject | Humans | |
dc.subject | Thrombelastography | |
dc.subject | Thrombosis | |
dc.subject | Journal Article | |
dc.subject | Review | |
dc.title | Endogenous Fibrinolysis : An Important Mediator of Thrombus Formation and Cardiovascular Risk | en |
dc.contributor.institution | Basic and Clinical Science Unit | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Pharmacy, Pharmacology and Postgraduate Medicine | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1016/j.jacc.2015.02.040 | |
rioxxterms.type | Other | |
herts.preservation.rarelyaccessed | true | |