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dc.contributor.authorOkafor, Osita N
dc.contributor.authorGorog, Diana A
dc.date.accessioned2019-05-10T14:04:52Z
dc.date.available2019-05-10T14:04:52Z
dc.date.issued2015-04-28
dc.identifier.citationOkafor , O N & Gorog , D A 2015 , ' Endogenous Fibrinolysis : An Important Mediator of Thrombus Formation and Cardiovascular Risk ' , Journal of the American College of Cardiology , vol. 65 , no. 16 , pp. 1683-1699 . https://doi.org/10.1016/j.jacc.2015.02.040
dc.identifier.issn0735-1097
dc.identifier.otherPURE: 13240694
dc.identifier.otherPURE UUID: b0bdaab1-2a6f-4ba4-ade6-8ee136bbb055
dc.identifier.otherPubMed: 25908074
dc.identifier.otherScopus: 84928019142
dc.identifier.urihttp://hdl.handle.net/2299/21326
dc.description© 2015 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION. PUBLISHED BY ELSEVIER INC.
dc.description.abstractMost acute cardiovascular events are attributable to arterial thrombosis. Plaque rupture or erosion stimulates platelet activation, aggregation, and thrombosis, whilst simultaneously activating enzymatic processes that mediate endogenous fibrinolysis to physiologically maintain vessel patency. Interplay between these pathways determines clinical outcome. If proaggregatory factors predominate, the thrombus may propagate, leading to vessel occlusion. However, if balanced by a healthy fibrinolytic system, thrombosis may not occur or cause lasting occlusion. Despite abundant evidence for the fibrinolytic system regulating thrombosis, it has been overlooked compared with platelet reactivity, partly due to a lack of techniques to measure it. We evaluate evidence for endogenous fibrinolysis in arterial thrombosis and review techniques to assess it, including biomarkers and global assays, such as thromboelastography and the Global Thrombosis Test. Global assays, simultaneously assessing proaggregatory and fibrinolytic pathways, could play a role in risk stratification and in identifying impaired fibrinolysis as a potential target for pharmacological modulation.en
dc.language.isoeng
dc.relation.ispartofJournal of the American College of Cardiology
dc.rightsOpen
dc.subjectAcute Coronary Syndrome
dc.subjectBiomarkers
dc.subjectCardiovascular Diseases
dc.subjectFibrinolysis
dc.subjectHumans
dc.subjectThrombelastography
dc.subjectThrombosis
dc.subjectJournal Article
dc.subjectReview
dc.titleEndogenous Fibrinolysis : An Important Mediator of Thrombus Formation and Cardiovascular Risken
dc.contributor.institutionBasic and Clinical Science Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2015-04-28
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.jacc.2015.02.040
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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